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The following safety information outlines the important warnings and precautions associated with the use of Zepbound (tirzepatide). It is crucial to understand these risks and consult with a healthcare professional if you have any concerns.

• Risk of Thyroid Cancer: Based on animal studies, there is a potential risk of developing thyroid tumors with Zepbound (tirzepatide). While it is not confirmed if this applies to humans, individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use this medication. Inform your doctor immediately if you experience symptoms such as a neck lump, difficulty swallowing, shortness of breath, or persistent hoarseness.

• Gastrointestinal Issues: This medication may cause stomach-related problems, including pain, nausea, vomiting, and diarrhea, which can occasionally be severe. It is not recommended for individuals with significant stomach issues like gastroparesis. If you experience these symptoms or have concerns, contact your prescriber.

• Kidney Damage: Zepbound (tirzepatide) can lead to kidney issues or worsen existing ones, especially if dehydration occurs due to side effects like vomiting or diarrhea. Individuals with a history of kidney problems should exercise caution.

• Gallbladder Problems: Although rare, gallbladder issues, such as gallstones, have been reported. Seek medical advice if you encounter severe stomach pain, nausea, vomiting, or fever.

• Pancreatitis: Some users have experienced inflammation of the pancreas. Discontinue use and contact your healthcare provider if you notice severe stomach or back pain or vomiting.

• Allergic Reactions: Serious allergic reactions can occur, especially in those with a history of reactions to similar medications. Seek emergency help for symptoms like difficulty breathing, swelling, or hives.

• Low Blood Sugar (Hypoglycemia): The risk of hypoglycemia exists, particularly when combined with insulin or sulfonylureas. Discuss potential dose adjustments with your prescriber to minimize this risk.

• Eye Complications in Type 2 Diabetes: Those with diabetic retinopathy may experience worsened eye conditions. Regular vision checks are necessary, and any unusual changes should be promptly addressed.

• Suicidal Thoughts and Behavior: Some individuals have reported changes in mood or behavior. Immediate medical help is advised if suicidal thoughts arise.

• Anesthesia Risks: Rarely, lung complications during anesthesia may occur due to delayed digestion. Follow pre-procedure fasting instructions carefully.

Contraindications: Do not use Zepbound (tirzepatide) if you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2. Always consult your healthcare provider before beginning treatment with this medication.

When taking this medication, it's common to experience mild side effects such as nausea, diarrhea, constipation, vomiting, stomach pain, and indigestion. These symptoms usually improve over time, but if they persist or worsen, it's advisable to consult a healthcare provider. Additionally, you might notice reactions at the injection site, fatigue, dizziness, burping, excessive gas, bloating, and even hair loss. These effects are generally manageable, but any concerns should be addressed with a healthcare professional.

It's crucial to be aware of more serious side effects, although they are rare. Immediate medical attention is necessary if you encounter symptoms of a serious allergic reaction, such as hives, breathing difficulties, or swelling of the face, lips, tongue, or throat. Watch for signs of dangerously low blood sugar, like hunger, fast heartbeat, shakiness, or dizziness. Kidney damage, indicated by nausea, vomiting, trouble urinating, or swelling in the ankles or feet, also requires prompt attention.

Moreover, inflammation of the pancreas can manifest as persistent nausea, vomiting, and stomach pain, while gallbladder issues might present as stomach pain, fever, or yellowing of the skin. If you experience any mental health changes, such as depression or suicidal thoughts, it's important to seek immediate help. Always communicate any unusual or severe symptoms to your healthcare provider for appropriate care and guidance.