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Here are important safety guidelines and warnings concerning the use of Orlistat. Please read through them carefully and consult with your healthcare provider if you have any questions or concerns.

• Medication Interactions: Orlistat may interact with other medications, potentially altering their effectiveness or the effectiveness of Orlistat itself. Notable interactions include those with cyclosporine, levothyroxine, warfarin, amiodarone, anti-seizure medications, and HIV medications. Inform your healthcare provider and pharmacist of all medications and supplements you are taking before beginning Orlistat. They can assist you in ensuring that your medications are scheduled appropriately to maximize their efficacy.

• Liver Injury: There is a risk of serious liver injury associated with Orlistat. Your healthcare provider will likely assess your liver function prior to starting treatment. If you have a history of liver problems, your provider may conduct more frequent liver tests. Seek immediate medical attention if you experience symptoms such as abdominal pain, dark urine, pale stools, jaundice, loss of appetite, or itching.

• Increased Urinary Oxalate Levels: Orlistat can lead to elevated levels of oxalate in the urine, which, although rare, can contribute to kidney stone formation. Your provider will monitor your kidney function before and during treatment to prevent kidney injury or stones. Report any symptoms such as pain in the lower back, bloody urine, nausea, vomiting, or unusual smelling or cloudy urine to your provider promptly.

• Gallstones: Weight loss associated with Orlistat may increase the risk of gallstones. In clinical studies, approximately 3% of participants taking Orlistat for diabetes prevention developed gallstones, compared to 2% of those on a placebo.

• Alternative Causes of Obesity: Before prescribing Orlistat, your provider will evaluate other potential causes of obesity. If conditions like hypothyroidism are discovered, treatment may involve medications specific to those conditions rather than weight loss drugs like Orlistat.

Contraindications: Orlistat is not suitable for use in certain conditions due to significant health risks. Consult your healthcare provider if any of the following apply to you:

• For Xenical (Orlistat):

  • Currently pregnant
  • Suffering from chronic malabsorption syndrome
  • Experiencing cholestasis (impaired bile flow from the liver)

• For Alli (Orlistat):

  • History of organ transplant
  • Taking cyclosporine (Sandimmune)
  • Experiencing problems with nutrient absorption
  • Not classified as overweight

Always discuss any medical conditions or concerns with your healthcare provider to determine if Orlistat is appropriate for you.

When using this medication, some individuals might encounter a range of side effects. Common side effects, which are usually mild, include oily spotting on underwear, gas with anal discharge, the urge to have a bowel movement, fatty or oily stool, increased frequency of bowel movements, and occasional difficulty controlling them. These effects vary, occurring in a small percentage of users, and while they may cause some discomfort, they often resolve on their own. However, if these symptoms persist or worsen, consulting a healthcare provider is advisable.

In addition to these, users may sometimes experience gas with oily spotting, loose stools, or more frequent stools that are harder to control. Although these are not as common, they should be monitored, and any significant discomfort should be reported to a healthcare professional.

Serious side effects, although rare, are important to recognize and address promptly. These include headaches, stomach pain or discomfort, back pain, changes in menstrual cycles, nausea, and rectal pain. If any of these occur, it is crucial to seek immediate medical attention to ensure appropriate care.