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Here are important safety guidelines and warnings concerning the use of Orlistat. Please read through them carefully and consult with your healthcare provider if you have any questions or concerns.

• Medication Interactions: Orlistat may interact with other medications, potentially altering their effectiveness or the effectiveness of Orlistat itself. Notable interactions include those with cyclosporine, levothyroxine, warfarin, amiodarone, anti-seizure medications, and HIV medications. Inform your healthcare provider and pharmacist of all medications and supplements you are taking before beginning Orlistat. They can assist you in ensuring that your medications are scheduled appropriately to maximize their efficacy.

• Liver Injury: There is a risk of serious liver injury associated with Orlistat. Your healthcare provider will likely assess your liver function prior to starting treatment. If you have a history of liver problems, your provider may conduct more frequent liver tests. Seek immediate medical attention if you experience symptoms such as abdominal pain, dark urine, pale stools, jaundice, loss of appetite, or itching.

• Increased Urinary Oxalate Levels: Orlistat can lead to elevated levels of oxalate in the urine, which, although rare, can contribute to kidney stone formation. Your provider will monitor your kidney function before and during treatment to prevent kidney injury or stones. Report any symptoms such as pain in the lower back, bloody urine, nausea, vomiting, or unusual smelling or cloudy urine to your provider promptly.

• Gallstones: Weight loss associated with Orlistat may increase the risk of gallstones. In clinical studies, approximately 3% of participants taking Orlistat for diabetes prevention developed gallstones, compared to 2% of those on a placebo.

• Alternative Causes of Obesity: Before prescribing Orlistat, your provider will evaluate other potential causes of obesity. If conditions like hypothyroidism are discovered, treatment may involve medications specific to those conditions rather than weight loss drugs like Orlistat.

Contraindications: Orlistat is not suitable for use in certain conditions due to significant health risks. Consult your healthcare provider if any of the following apply to you:

• For Xenical (Orlistat):

  • Currently pregnant
  • Suffering from chronic malabsorption syndrome
  • Experiencing cholestasis (impaired bile flow from the liver)

• For Alli (Orlistat):

  • History of organ transplant
  • Taking cyclosporine (Sandimmune)
  • Experiencing problems with nutrient absorption
  • Not classified as overweight

Always discuss any medical conditions or concerns with your healthcare provider to determine if Orlistat is appropriate for you.

When taking Xenical (orlistat), it's important to be aware of potential interactions with other medications:

• Cyclosporine: Xenical can reduce the levels of cyclosporine in your blood, potentially decreasing its effectiveness. To minimize this interaction, take cyclosporine at least three hours before or after Xenical.

• Levothyroxine: Combining Xenical with levothyroxine may lead to hypothyroidism. To reduce this risk, take levothyroxine and Xenical at least four hours apart and monitor your thyroid function regularly.

• Warfarin and Other Anticoagulants: Xenical may decrease the absorption of vitamin K, which is essential for blood clotting. This can affect the effectiveness of anticoagulants like warfarin. If you're on such medications, your doctor should closely monitor your blood clotting parameters.

• Amiodarone: Taking Xenical with amiodarone may reduce the levels of amiodarone in your blood, potentially diminishing its therapeutic effect. The clinical significance of this interaction is not fully understood, so consult your healthcare provider for guidance.

• Antiepileptic Drugs: There have been reports of increased seizure frequency in patients taking Xenical alongside antiepileptic medications. If you're on antiepileptic drugs, monitor for any changes in seizure activity.

• Antiretroviral Drugs: Some HIV-infected patients have experienced a loss of virological control when taking Xenical with antiretroviral medications. Regular monitoring of HIV RNA levels is recommended, and if an increase is observed, discontinuing Xenical may be necessary.

• Fat-Soluble Vitamins: Xenical can reduce the absorption of vitamins A, D, E, K, and Beta-Carotene. To ensure adequate nutrition, consider taking a daily multivitamin supplement containing these vitamins at least two hours before or after Xenical.

Always inform your healthcare provider about all medications and supplements you're taking to manage potential interactions effectively.