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This safety information outlines crucial warnings and precautions associated with the use of phendimetrazine. Please read the details carefully and consult your healthcare provider if you have any concerns or questions.

• Avoid Combining with Other Weight Loss Medications: Phendimetrazine should not be used alongside other weight loss drugs, including over-the-counter options. Consult your healthcare provider for guidance on your treatment plan.

• Tolerance Development: Over time, phendimetrazine may become less effective, a condition known as tolerance. Increasing the dosage is not recommended and can lead to serious side effects. Contact your healthcare provider if you observe a return of appetite or weight gain for alternative treatment suggestions.

• Risk of Misuse and Dependence: Phendimetrazine carries a risk of misuse and dependence similar to other stimulants, potentially leading to stimulant use disorder. To mitigate this risk, the medication is typically prescribed in limited amounts and should be taken as directed, usually for a short-term period of a few weeks. Discuss long-term weight management options with your healthcare provider if needed.

• Pulmonary Hypertension Risk: Rare but serious, phendimetrazine can cause high blood pressure in the lungs (pulmonary hypertension), especially if used longer than three months. Seek immediate medical attention if you experience breathing difficulties, chest pain, fainting, or leg swelling.

• Heart Valve Issues: Use of stimulants like phendimetrazine can lead to heart valve problems, particularly with long-term use or when combined with other appetite suppressants. Report any symptoms such as dizziness, chest pain, swelling in legs or ankles, irregular heartbeat, fatigue, or breathing difficulties to your healthcare provider.

• High Blood Pressure Risk: Phendimetrazine may increase blood pressure. If you have high blood pressure, inform your healthcare provider, as you may need to monitor your blood pressure more frequently during treatment.

• Low Blood Sugar Risk in Diabetes: Diabetic individuals using insulin or sulfonylureas like glipizide may experience low blood sugar due to changes in appetite induced by phendimetrazine. Your diabetes management plan may require adjustments in medication dosages.

Contraindications: Phendimetrazine should not be used in the following conditions due to potential serious health risks:

• Heart problems (e.g., coronary artery disease, stroke, irregular heartbeat, untreated high blood pressure, congestive heart failure)
• Recent use of monoamine oxidase inhibitors (MAOI) within the past 14 days
• Concurrent use of other weight-loss medications
• Overactive thyroid (hyperthyroidism)
• Glaucoma
• Experiencing agitation or distress
• History of substance use disorder
• Pregnancy or breastfeeding

It is imperative to discuss your medical history and any existing health conditions with your healthcare provider before starting phendimetrazine to ensure safe and effective use.

Common side effects:

• Dizziness
• Dry mouth
• Difficulty sleeping
• Irritability
• Restlessness
• Nervousness
• Shakiness
• Sweating
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Changes in sex drive

Serious side effects:

• Fast or irregular heartbeat
• Agitation
• Uncontrolled anger
• Hallucinations
• Uncontrolled muscle movements
• Significant mental or mood changes
• Severe headache
• Trouble speaking
• Seizures
• Weakness on one side of the body
• Pulmonary hypertension
• Heart valve problems
• Chest pain
• Difficulty breathing during exercise
• Decreased exercise ability
• Fainting
• Swelling of the legs, ankles, or feet
• Allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Stimulants (including amphetamines, Methylphenidate, cocaine, MDMA)
• Appetite suppressants (such as phentermine, ephedra/ma huang)
• MAO inhibitors (isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)
• Brofaromine
• Clorgyline
• Furazolidone
• Iproniazid
• Lazabemide
• Nialamide
• Pargyline
• Sibutramine
• Toloxatone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Iobenguane I 131

Interactions with low risk that usually do not require a change in therapy:

• Drowsiness-inducing products (opioids like codeine, hydrocodone, alcohol, cannabis, sleep aids like Alprazolam, Lorazepam, Zolpidem, muscle relaxants like Carisoprodol, Cyclobenzaprine, antihistamines like Cetirizine, diphenhydramine)
• Products that elevate heart rate/blood pressure (certain cough-and-cold medicines, diet aids)
• Caffeine (coffee, tea, colas, chocolate)