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This medication is a combination of bupropion and naltrexone, used for various conditions including weight loss. It is important to be aware of the potential risks and precautions associated with its use. Below are key safety considerations and warnings to discuss with your healthcare provider:

• Suicidal Thoughts and Behavior: Bupropion, one component of this medication, may increase the risk of depression worsening, suicidal thoughts, or unusual behavior changes, particularly in individuals younger than 25 or those with a history of mental health conditions. Be vigilant for changes in mood or behavior, especially when starting or adjusting the dosage, and seek immediate medical help if these occur.

• Seizures: While rare, bupropion can cause seizures, particularly at higher doses. Inform your healthcare team of your medical history, including any history of seizures, eating disorders, head injuries, or substance use, as well as any medications you are taking that may increase seizure risk.

• Drug Interactions: Avoid taking this medication with opioids, as it can lead to dangerous withdrawal symptoms or overdose. Also, do not combine it with other bupropion-containing medications or monoamine oxidase inhibitors (MAOIs).

• Cardiovascular Effects: This medication can increase heart rate and blood pressure, particularly in the initial months of treatment. Discuss with your doctor if you have a history of high blood pressure.

• Liver Health: Some individuals have experienced liver issues when taking naltrexone. Ensure your healthcare provider is aware of any liver concerns or medications that may affect liver function.

• Manic Episodes: There is a possibility of experiencing manic episodes, characterized by extreme enthusiasm or irritability, particularly if you have bipolar disorder or a family history of mood disorders. Monitor for mood changes and contact your healthcare provider if they occur.

• Glaucoma: If you have angle-closure glaucoma, this medication could worsen your condition. Inform your healthcare provider about any eye health issues prior to starting treatment.

• Low Blood Sugar in Type 2 Diabetes: Weight loss associated with this medication may lead to low blood sugar in individuals with Type 2 diabetes who are taking insulin or other diabetes medications. Monitor blood sugar levels closely.

• Contraindications: Do not use this medication if you have uncontrolled high blood pressure, a history of seizures or eating disorders, recently stopped consuming alcohol or certain medications, or if you are allergic to bupropion or naltrexone.

In case of overdose, seek emergency medical assistance immediately. Always consult with your healthcare provider to ensure this medication is safe and appropriate for your specific health needs.

When taking this medication, you might experience some common side effects. These include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, diarrhea, and a strange taste in the mouth. While these effects are usually mild, if they persist or worsen, it's advisable to consult your healthcare provider. It's worth noting that many people using this medication do not experience serious side effects.

Other side effects that may occur include stomachache, shakiness, increased sweating, ringing in the ears, fatigue, sudden hot flashes, anxiety, irritability, higher blood pressure, flu-like symptoms, and urinary tract infections. Although these effects are less common, they should be monitored, especially if they become severe.

There are more serious side effects that, although rare, require immediate medical attention. These include thoughts of self-harm or suicidal behavior, seizures, and severe allergic reactions characterized by rash, hives, blistering or peeling skin, chest pain, shortness of breath, and swelling. If you experience any of these symptoms, seek urgent medical care.

Additionally, for individuals taking opioid medications regularly, there is a risk of withdrawal symptoms such as mental or mood changes, fast breathing, yawning, sweating, watering eyes, goosebumps, and muscle twitching. Very rarely, this drug can cause seizures. If a seizure occurs, discontinue use and contact a healthcare professional immediately. Furthermore, naltrexone may rarely lead to serious liver disease, especially with higher doses. Symptoms of liver damage include persistent nausea or vomiting, loss of appetite, severe stomach or abdominal pain, yellowing of the eyes or skin, and dark urine. Seek medical attention if these occur.

A very serious allergic reaction is rare, but if you notice symptoms such as rash, itching, severe dizziness, or trouble breathing, seek medical help immediately. This summary does not cover all potential side effects; for any other effects, please consult your doctor or pharmacist.