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This medication combines bupropion and naltrexone. Bupropion is primarily an antidepressant used to manage various conditions such as depression and other mental/mood disorders. It is also prescribed for smoking cessation and weight management. Antidepressants can offer critical benefits, including the prevention of suicidal thoughts and attempts. However, research indicates that a small percentage of individuals, particularly those under 25, may experience a worsening of depression, mental/mood symptoms, or suicidal thoughts/attempts when taking antidepressants. It is crucial to discuss the potential risks and benefits of antidepressant use with a healthcare provider, especially for patients under 25, regardless of whether the treatment is for a mental/mood condition.

Please contact your healthcare provider immediately if you observe any worsening of depression or psychiatric conditions, unusual behavioral changes (including potential suicidal thoughts/attempts), or other mental/mood alterations such as new or worsening anxiety, panic attacks, sleep disturbances, irritability, hostile or angry feelings, impulsive actions, severe restlessness, or very rapid speech. These symptoms require vigilant observation, particularly when initiating a new antidepressant or modifying the dosage.

For individuals using the combination of naltrexone and bupropion for weight loss, discontinue the medication and inform your healthcare provider immediately if you encounter any of the symptoms mentioned above. This applies even after the cessation of treatment.

When taking this medication, some common side effects may include nausea, vomiting, constipation, stomach pain, headache, dizziness, trouble sleeping, increased sweating, flushing, and a dry or unusual taste in the mouth. These are generally mild and often improve as your body adjusts to the medication. However, if they persist or worsen, consult your healthcare provider.

Serious side effects are less common but require immediate attention. These include mental or mood changes like anxiety, agitation, confusion, or memory loss, as well as uncontrolled movements, ringing in the ears, fainting, severe headache, irregular heartbeat, or chest pain. If you experience these symptoms, contact your healthcare professional promptly.

In rare cases, very serious side effects such as eye pain or swelling, widened pupils, vision changes, or symptoms of a severe allergic reaction like rash, swelling, severe dizziness, or trouble breathing can occur. Seek emergency medical help immediately if these arise.

This medication can also cause withdrawal symptoms, especially if you have been using opioids regularly. Symptoms include anxiety, irritability, fast breathing, yawning, sweating, watering eyes, goose bumps, and muscle twitching. Notify your doctor if you experience these.

Seizures are another rare but serious risk; if one occurs, seek medical attention immediately and discontinue use. Similarly, naltrexone can rarely lead to severe liver damage, particularly at higher doses. Signs of liver damage include persistent nausea, loss of appetite, severe stomach pain, yellowing of the eyes or skin, and dark urine. Discontinue use and inform your doctor if these symptoms occur.

While a severe allergic reaction is rare, it requires urgent medical care. This summary does not cover all possible side effects, so if you notice others, consult your healthcare provider.