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Nevirapine

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generic Viramune

Nevirapine, known under the brand name Viramune, is used in combination with other medications to manage HIV infection. It works by reducing the amount of HIV in the body, which supports better immune function and lowers the risk of complications such as new infections or cancer, thereby enhancing the quality of life. Nevirapine is classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI), which operates by blocking the enzyme reverse transcriptase that HIV uses to replicate. This action helps prevent the spread of the virus. Nevirapine is available in immediate-release and extended-release forms, as well as an oral suspension for those who have difficulty swallowing, including children. While effective, it is important to note that Nevirapine is not a cure for HIV. To minimize the risk of transmitting HIV to others, it is crucial to continue all prescribed HIV medications, use protective barriers like condoms during sexual activity, and avoid sharing personal items that may contact blood or bodily fluids. It is not recommended to use Nevirapine for preventing HIV infection following accidental exposure, such as needlestick injuries; other medications are indicated for such situations. Be aware that in rare cases, Nevirapine can cause a severe rash within the first four months of treatment, and immediate medical attention should be sought if this occurs. Always consult your healthcare provider for personalized medical advice.
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Nevirapine WarningsNevirapine Side EffectsNevirapine InteractionsFAQs

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200MG, Nevirapine (30 Tablets)

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The average cost for 30 Tablets of Nevirapine (generic Viramune) at 200MG is $8 with a free coupon. This is 2.46% off the average retail price of $324.9
DosageQuantityPrice fromPer unit
200MG30 Tablets$8$0.27

Nevirapine Warnings

Nevirapine, marketed as Viramune, is associated with significant safety warnings. It is crucial for patients and healthcare professionals to be aware of these potential risks and take appropriate precautions. Below are important considerations for the safe use of this medication:

  • Liver Problems: Nevirapine can cause serious, potentially fatal liver issues, especially within the first four months of treatment. Women, individuals with high white blood cell counts, and those with hepatitis B or C are at higher risk. It is essential to conduct liver function tests before and during treatment. If you have a history of moderate to severe liver problems, do not use this medication. Watch for symptoms like persistent nausea, loss of appetite, vomiting, abdominal pain, dark urine, pale stools, yellowing of the eyes or skin, and unusual fatigue. Immediate medical attention is necessary if these symptoms arise.

  • Skin and Allergic Reactions: Severe skin and allergic reactions, occasionally life-threatening, may occur, particularly within the first six weeks of treatment. Women are more susceptible. Initial doses are lower to monitor tolerance. If you experience symptoms such as a severe rash with fever, body aches, mouth sores, blisters, or facial swelling, discontinue use and seek medical help immediately.

  • Immune System Changes: Starting nevirapine in combination with other HIV medications may lead to immune reconstitution syndrome, where the immune system becomes overactive, potentially attacking normal cells. Symptoms can include fever, pain, hair loss, bulging eyes, or sweating. Inform your healthcare provider promptly if these occur.

  • Body Fat Changes: Some users of HIV medications, including nevirapine, have reported changes in body fat distribution. These involve fat buildup in areas like the back of the neck or abdomen, and fat loss from limbs or face. The exact cause and long-term health effects are unclear. Report any noticeable changes to your healthcare provider.

  • Drug Interactions: Nevirapine's effectiveness and safety can be affected by interactions with other drugs, altering how it is metabolized. Inform your healthcare provider about all medications you are taking to manage potential interactions.

  • Contraindications: Do not use nevirapine if you have moderate to severe liver problems or are undergoing post-exposure prophylaxis (PEP) treatment.

  • Emergency Actions: If an overdose is suspected, seek emergency medical attention immediately.

Always keep all medical and lab appointments to ensure your response to nevirapine is closely monitored. If you have discontinued nevirapine due to liver or allergic reactions, never restart it. Inform all healthcare providers of any past adverse reactions to this medication.

Nevirapine Side Effects

Tiredness, nausea, vomiting, or diarrhea may occur. Drowsiness may rarely occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. As your immune system gets stronger, it can begin to fight off infections you already had, possibly causing disease symptoms to come back. You could also have symptoms if your immune system becomes overactive. This reaction may happen at any time (soon after starting HIV treatment or many months later). Tell your doctor right away if you have any serious symptoms, including: unexplained weight loss, severe tiredness, muscle aches/weakness that doesn't go away, headaches that are severe or don't go away, joint pain, numbness/tingling of the hands/feet/arms/legs, vision changes, signs of infection (such as sore throat that doesn't go away, fever, chills, non-healing skin sores), signs of an overactive thyroid (such as irritability, nervousness, heat intolerance, fast/pounding/irregular heartbeat). Nevirapine can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash. Changes in body fat may occur while you are taking this medication (such as increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cause and long-term effects of these changes are unknown. Discuss the risks and benefits of treatment with your doctor, as well as the possible use of exercise to reduce this side effect. A very serious allergic reaction to this drug is rare, but get medical help right away if it occurs. See the Warning section for more details. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Nevirapine Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • Orlistat
  • Rifabutin
  • Warfarin
  • Rifampin
  • St. John's wort
  • Prednisone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • Amiodarone
  • Atazanavir
  • Cobicistat
  • Clonazepam
  • Itraconazole
  • Ketoconazole
  • Clarithromycin
  • Methadone

Interactions with low risk that usually do not require a change in therapy:

  • Hormonal birth control methods such as pills, patch, or ring
Nevirapine FAQs
What is nevirapine medicine used for?

Nevirapine is used as part of antiretroviral therapy for the treatment of HIV-1 infection. It helps to reduce the amount of HIV in the body, thereby improving the immune system function and reducing the risk of developing HIV-related illnesses.

Nevirapine is an antiretroviral medication used to prevent mother-to-child transmission of HIV during childbirth. When administered to newborns, it helps reduce the risk of the baby acquiring HIV from an HIV-positive mother. It is typically given as part of a combination therapy to enhance its effectiveness.

Yes, nevirapine is still used as part of antiretroviral therapy for the treatment of HIV-1 infection. It is often used in combination with other antiretroviral medications. However, its use may be limited due to potential side effects and the availability of newer medications with improved safety profiles. It is important for patients to consult with their healthcare provider to determine the most appropriate treatment regimen for their specific condition.

Nevirapine in infants can cause several side effects. Common side effects include rash, fever, and liver function abnormalities. In some cases, more severe side effects such as severe skin reactions or liver toxicity may occur. It is important for caregivers to monitor infants closely for any signs of adverse reactions and to consult a healthcare provider if any concerning symptoms arise.

An alternative to nevirapine, which is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV, could include other NNRTIs such as efavirenz, etravirine, or rilpivirine. Additionally, integrase inhibitors like dolutegravir or protease inhibitors such as atazanavir might be considered, depending on the specific treatment regimen and patient needs. It is important for a healthcare provider to determine the most appropriate alternative based on the individual's health status and treatment history.

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