Acamprosate

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Acamprosate is a medication prescribed to support individuals with alcohol use disorder in maintaining abstinence from alcohol. It is most effective for adults who have already stopped drinking. The drug functions by modulating the N-methyl-D-aspartate (NMDA) receptors, helping to restore the balance of certain neurotransmitters in the brain, such as gamma-aminobutyric acid (GABA) and glutamate. This action helps to reduce the craving for alcohol. Acamprosate is typically taken orally three times a day. Some common side effects include diarrhea, trouble sleeping, and nervousness. It is available in generic form, as the brand name Campral has been discontinued. Before beginning treatment with Acamprosate, it is important to cease alcohol consumption, as the medication is not effective for those who continue to drink while taking it. Always consult with a healthcare professional before starting any new medication.
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333MG, Acamprosate (30 Tablet Delayed Releases)

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CVS

$24.72

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$11.70

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$18.07

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$20.24

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$32.47

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Acamprosate savings card

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Acamprosate dosage forms

The average cost for 30 Tablet Delayed Releases of Acamprosate at 333MG is $11.7 with a free coupon. This is 25.00% off the average retail price of $46.8
DosageQuantityPrice fromPer unit
333MG30 Tablet Delayed Releases$11.7$0.39

Acamprosate Warnings

This document provides essential safety and warning information regarding the use of this medication. Please review the details carefully and consult your healthcare provider if you have any questions or concerns.

  • Suicidal Thoughts and Behavior: Although not frequent, individuals taking acamprosate in clinical trials reported higher rates of suicidal thoughts and behaviors compared to those receiving a placebo. Such thoughts often emerged during alcohol relapse. It is crucial to maintain close communication with your healthcare team throughout your alcohol recovery journey. Promptly report any signs of mood deterioration or thoughts of self-harm. Inform family members and loved ones about your treatment so they can observe and report any behavioral changes to your healthcare provider if necessary.

  • Kidney Function Concerns: Acamprosate is eliminated from the body by the kidneys. If your kidneys do not function properly, the medication may accumulate in your system. Individuals with mild kidney impairment might need to take half the standard dose. Those with severe kidney issues should avoid using acamprosate.

  • Effectiveness for Alcohol Withdrawal: Studies indicate that acamprosate may not be effective for alleviating alcohol withdrawal symptoms. It is intended for use after cessation of alcohol consumption and completion of the initial withdrawal phase. However, treatment with acamprosate can continue if a relapse occurs. Regular consultations with your healthcare team are important to receive ongoing support and resources necessary for sustaining recovery.

Contraindications: This medication should not be used in the presence of certain conditions, as it may pose significant health risks. Consult your healthcare provider if any of the following apply to you:

  • Severe kidney problems

Acamprosate Side Effects

Common side effects:

  • Diarrhea
  • Nausea
  • Vomiting
  • Gas
  • Stomach pain
  • Headaches
  • Drowsiness
  • Dizziness
  • Tiredness
  • Changes in weight
  • Changes in appetite
  • Changes in sexual desire
  • Trouble sleeping
  • Nervousness
  • Anxiety
  • Physical weakness
  • Dry mouth

Serious side effects:

  • Mental or mood changes (such as depression or suicidal thoughts)
  • Signs of kidney problems (like changes in urine output)
  • Fainting
  • Rapid heartbeat
  • Vision or hearing alterations
  • Persistent stomach pain
  • Black stools
  • Vomit resembling coffee grounds
  • Seizures
  • Allergic reaction (rash, itching, swelling of face, tongue, or throat, severe dizziness, difficulty breathing)
Acamprosate FAQs
What is the controversy with acamprosate?

The controversy surrounding acamprosate primarily involves its effectiveness in treating alcohol dependence. Some studies have shown that acamprosate can be effective in reducing alcohol consumption and supporting abstinence, while other studies have found its benefits to be minimal or not significantly different from placebo. This inconsistency in research findings has led to debates among healthcare professionals regarding its clinical utility. Additionally, there are discussions about its cost-effectiveness compared to other treatment options.

Acamprosate is not typically used to calm someone down. It is primarily prescribed to help maintain abstinence in individuals with alcohol dependence by restoring the balance of neurotransmitters in the brain. It does not have sedative or anxiolytic properties. If someone is seeking medication for anxiety or calming effects, they should consult with a healthcare provider for appropriate options.

Antabuse and Campral are not the same. Antabuse (disulfiram) is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol. Campral (acamprosate), on the other hand, is used to help maintain abstinence in people who have stopped drinking alcohol by stabilizing the chemical balance in the brain. They work differently and are used for different purposes in the management of alcohol dependence.

Acamprosate is used to help maintain abstinence in individuals with alcohol dependence. Its success rate can vary depending on several factors, including adherence to the medication regimen and participation in a comprehensive treatment program. Clinical studies have shown that acamprosate can increase the likelihood of maintaining abstinence, with some studies reporting success rates of around 30-50% when used as part of a complete treatment plan that includes counseling and support. It is important to note that individual results may vary, and success is often greater when combined with other therapeutic interventions.

Acamprosate does not have a black box warning. However, it is important for patients to discuss any potential risks and side effects with their healthcare provider before starting the medication.