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Diazepam is a medication that requires careful use due to its potential risks and interactions. Below are crucial safety warnings and precautions to consider before using Diazepam. Please consult your healthcare provider if you have any questions or concerns.

• Risk of Abuse and Dependence: Diazepam can lead to misuse and addiction, potentially resulting in overdose and death. It is important to take Diazepam exactly as prescribed by your healthcare provider and avoid combining it with alcohol or other drugs that can cause drowsiness or breathing issues, especially opioids like codeine or hydrocodone.

• Interactions with Other Substances: Combining Diazepam with opioids or alcohol can cause severe drowsiness and breathing problems, which can be fatal. Be sure to discuss all medications you are taking with your healthcare provider, including over-the-counter drugs and supplements, to avoid dangerous interactions.

• Withdrawal Risks: Discontinuing Diazepam abruptly, especially after prolonged use or at high doses, can lead to withdrawal symptoms such as headaches, restlessness, nausea, and seizures. Your doctor may gradually reduce your dose to prevent withdrawal effects.

• Special Considerations for Pregnant and Breastfeeding Individuals: If you are pregnant or breastfeeding, inform your healthcare provider, as Diazepam may pose risks to your baby, including birth defects and withdrawal symptoms at birth. Consider enrolling in the North American Antiepileptic Drug (NAAED) Pregnancy Registry to help monitor the safety of such medications during pregnancy.

• Use in Individuals with Depression: Diazepam can exacerbate depression and may lead to manic episodes. Monitor for any changes in mood, suicidal thoughts, or behaviors, and seek medical attention if these occur.

• Emergency Situations: Seek immediate medical help if you experience serious side effects such as difficulty breathing, extreme drowsiness, or trouble waking up.

• Contraindications: Certain conditions, such as being under six months of age, having myasthenia gravis, severe breathing or liver problems, sleep apnea, and acute narrow-angle glaucoma, may contraindicate the use of Diazepam. Discuss your medical history with your healthcare provider to ensure safe use of this medication.

Always prioritize open communication with your healthcare provider to manage your treatment effectively and minimize risks.

Common side effects:

• drowsiness
• dizziness
• blurred vision
• unsteadiness
• muscle weakness
• issues with balance and coordination

Less common but important to monitor:

• confusion
• depression
• trouble speaking
• nausea
• headache
• changes in behavior or sleep

Serious side effects:

• dangerously slow breathing
• severe sedation
• withdrawal symptoms
• uncontrolled movements
• anxiety
• panic attacks
• hallucinations
• convulsions
• chest pain
• fainting
• yellowing of the eyes or skin
• signs of infection
• persistent sore throat
• fever
• rash
• trouble breathing
• itching
• swelling of the face, tongue, or throat
• severe dizziness

Interactions with high risk of serious adverse effects and should be avoided:

• Flumazenil

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Clozapine
• Fluvoxamine
• Orlistat
• Sodium Oxybate
• Alprazolam
• Codeine
• Zolpidem
• Amitriptyline
• Opioid pain relievers (such as codeine, hydrocodone)
• Alcohol
• Marijuana (cannabis)
• Other drugs for sleep or anxiety (such as Lorazepam)
• Muscle relaxants (such as Carisoprodol, Cyclobenzaprine)
• Antihistamines (such as Cetirizine, diphenhydramine)