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You might experience some common side effects such as nausea, headache, dizziness, drowsiness, anxiety, tiredness, or a reduced appetite. These are usually mild and often improve as your body adjusts to the medication. If you've been using opiates regularly, mild withdrawal symptoms like abdominal cramps, restlessness, bone or joint pain, muscle aches, and a runny nose may occur. Injection site issues such as pain, redness, swelling, itching, or bruising can happen, but if they persist or worsen over two weeks, seek advice from a healthcare professional.

In rare cases, severe reactions at the injection site can lead to permanent injury if untreated. Immediate medical attention is necessary if sudden opiate withdrawal symptoms arise, such as vomiting, diarrhea, or significant mental changes like anxiety or confusion. Serious side effects like fast or irregular heartbeats, depression, signs of breathing problems, or severe injection site reactions require prompt consultation with a healthcare provider.

Naltrexone can rarely cause liver issues, especially with higher doses. Symptoms of liver damage include persistent nausea, dark urine, and yellowing of the skin or eyes. Discontinue use and seek medical help if these occur. Although a severe allergic reaction is rare, symptoms such as rash, swelling, severe dizziness, or trouble breathing need immediate medical care. Always inform your healthcare provider about any unusual side effects you experience.