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The safety and warning information for benzphetamine is crucial for understanding its potential risks and necessary precautions. Please review the following points carefully and consult your healthcare provider with any questions or concerns.

• Avoidance with Other Weight Loss Medications: Do not use benzphetamine within one year of taking other weight loss medications, including over-the-counter options, due to an increased risk of severe side effects such as heart or respiratory issues. Discuss your treatment plan with your healthcare team if you have concerns.

• Tolerance Development: Benzphetamine is intended for short-term use, as prolonged use may lead to decreased effectiveness. Do not increase your dose without consulting your healthcare provider, as this can result in serious side effects. Notify your prescriber if you experience weight gain or a return of appetite during treatment.

• Risk of Misuse and Dependence: Benzphetamine carries a risk of misuse and dependence similar to other stimulants, which can lead to a stimulant use disorder. To minimize this risk, take the medication exactly as prescribed, typically for just a few weeks. Discuss long-term weight management strategies with your healthcare provider.

• Pulmonary Hypertension: Rarely, benzphetamine can lead to high blood pressure in the lungs, which is potentially life-threatening. This risk increases with use beyond three months. Seek immediate medical help if you experience symptoms like difficulty breathing, chest pain, fainting, or leg swelling.

• Heart Valve Issues: There is a risk of heart valve problems, particularly with long-term use or if combined with other appetite-suppressing drugs. Report symptoms such as dizziness, chest pain, swelling of the legs or ankles, irregular heartbeat, fatigue, or breathing difficulties to your prescriber.

• Blood Pressure Concerns: Benzphetamine can increase the risk of high blood pressure. Inform your healthcare provider if you have high blood pressure, even if it is well-managed, as frequent monitoring may be necessary during treatment.

• Low Blood Sugar in Diabetics: Individuals with diabetes using blood sugar-lowering medications, such as insulin, may experience low blood sugar due to appetite changes. Your diabetes care team may need to adjust your medication dosage accordingly.

Contraindications: Benzphetamine should not be used if you have any of the following conditions, as it poses serious health risks. Consult your healthcare provider if any apply to you:

• Heart issues (e.g., coronary artery disease, stroke, irregular heartbeat, uncontrolled high blood pressure, congestive heart failure)
• Recent use of monoamine oxidase inhibitors (MAOIs) within the last 14 days
• Concurrent use of other weight-loss medications
• Overactive thyroid (hyperthyroidism)
• Glaucoma
• Agitation or distress
• History of substance use disorder
• Pregnancy or breastfeeding

Ensure to adhere to these guidelines and discuss any concerns with your healthcare provider to ensure safe and effective treatment with benzphetamine.

Common side effects:

• dizziness
• dry mouth
• difficulty sleeping
• irritability
• nausea
• vomiting
• diarrhea
• constipation
• increased blood pressure

Less common but important to monitor:

• fast or irregular heartbeat
• mood changes like agitation or nervousness
• uncontrolled muscle movements
• alterations in sexual interest or ability

Serious side effects:

• severe headache
• speech difficulties
• seizures
• weakness on one side of the body
• vision changes like blurred vision
• pulmonary hypertension
• heart valve problems
• chest pain
• difficulty breathing
• fainting
• swelling in the legs, ankles, or feet
• allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Isocarboxazid
• Linezolid
• Methylene Blue
• Moclobemide
• Phenelzine
• Procarbazine
• Rasagiline
• Safinamide
• Selegiline
• Tranylcypromine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Phentermine
• Ephedra/Ma Huang
• Phenothiazines (e.g., Prochlorperazine, Chlorpromazine)
• Stimulants (e.g., amphetamines, Methylphenidate, cocaine, MDMA)
• Caffeine

Interactions with low risk that usually do not require a change in therapy:

• Cough-and-cold products
• Diet aids