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This section outlines critical safety information and warnings associated with the use of Adlyxin (lixisenatide). It is crucial to review these carefully and discuss any concerns with your healthcare provider.

• Pancreatitis (Inflammation of the Pancreas): In rare cases, Adlyxin may lead to pancreatitis, which can be severe. Seek immediate medical attention if you experience intense abdominal or back pain, vomiting, high fever, or rapid heartbeat. Individuals with a history of pancreatitis, gallstones, alcoholism, or elevated triglycerides are at higher risk.

• Severe Allergic Reactions: Though uncommon, severe allergic reactions to Adlyxin can occur. Symptoms include rash, blistering, difficulty breathing, or swelling of the lips, tongue, mouth, or throat. Discontinue use and seek emergency medical care if these symptoms arise.

• Kidney Damage: Adlyxin may cause or exacerbate kidney damage. Notify your healthcare provider if you experience difficulty urinating. Those with pre-existing kidney issues should consult their healthcare provider before using Adlyxin, as monitoring or alternative treatments may be necessary. Risks are elevated for individuals with kidney disease, end-stage renal disease (ESRD), or dehydration.

• Hypoglycemia (Low Blood Sugar): The likelihood of hypoglycemia increases when Adlyxin is used in conjunction with insulin or medications that increase insulin levels, such as sulfonylureas. In the event of low blood sugar, consume a fast-acting sugar immediately. Consult your healthcare provider or pharmacist for guidance on managing low blood sugar and adjusting doses of other diabetes medications when starting Adlyxin.

Please ensure to discuss these potential risks and precautions with your healthcare provider to optimize your treatment and maintain your health and safety.

When using Adlyxin (lixisenatide) to manage type 2 diabetes, it's important to be aware of potential interactions with other medications and substances. Adlyxin can slow down the emptying of your stomach, which may affect how your body absorbs certain oral medications. This could lead to changes in how well these medications work.

Oral Medications:

• Antibiotics and Acetaminophen: To ensure these medications are absorbed properly, take them at least one hour before your Adlyxin injection. If you need to take them with food, choose a meal or snack when you're not administering Adlyxin.

• Oral Contraceptives: Adlyxin may reduce the effectiveness of birth control pills taken by mouth. To maintain their effectiveness, take your oral contraceptive at least one hour before or at least 11 hours after your Adlyxin injection.

Other Diabetes Medications:

• Sulfonylureas and Insulin: Combining Adlyxin with sulfonylureas (like Glimepiride, Glyburide, or Glipizide) or insulin can increase the risk of low blood sugar (hypoglycemia). Your healthcare provider may need to adjust the doses of these medications to reduce this risk.

Herbal Supplements:

• Arabinoxylan: This fiber supplement can lower blood sugar levels. When taken with Adlyxin, it might further increase the risk of hypoglycemia. Monitor your blood sugar levels closely and consult your healthcare provider for possible dose adjustments.

Alcohol:

• Alcohol Consumption: Drinking alcohol while on Adlyxin can affect your blood sugar levels, potentially leading to either low or high blood sugar. It's advisable to limit alcohol intake and discuss safe consumption levels with your healthcare provider.

Always inform your healthcare provider about all the medications, supplements, and substances you are using. They can provide guidance on how to manage these interactions effectively.