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Below are important safety warnings regarding the use of alogliptin (Nesina). It is crucial to understand these potential risks and consult your healthcare provider with any concerns:

• Heart Failure Risk: Individuals who have recently experienced an acute coronary syndrome (ACS), such as a heart attack, are at increased risk for heart-related issues, including heart failure, especially within the first six months post-ACS. Alogliptin (Nesina) may heighten this risk. Immediate medical attention is advised if symptoms such as breathlessness during routine activities, fatigue, or swelling in the legs, ankles, or feet occur. A history of heart failure, kidney issues, or recent ACS increases this risk.

• Severe Joint Pain: Some individuals have reported severe joint pain shortly after starting a DPP-4 inhibitor like alogliptin (Nesina), with symptoms disappearing upon discontinuation of the medication. If severe joint pain arises, consult your healthcare provider to discuss whether to continue the medication.

• Pancreatitis: While rare, inflammation of the pancreas (pancreatitis) has been observed in patients taking alogliptin (Nesina). Symptoms include upper stomach pain, fever, nausea, and vomiting. Contact your healthcare provider immediately if these symptoms occur, as they may advise stopping the medication.

• Liver Problems: There are very rare instances of liver damage, potentially fatal, associated with alogliptin (Nesina). Symptoms to watch for include yellowing of the skin, fatigue, dark urine, and upper right stomach pain. Report these to your provider immediately for liver function assessment and possible discontinuation of the medication.

• Severe Itchy Rash: Rarely, an itchy, blistering rash (pemphigoid) may develop after starting alogliptin (Nesina), caused by an immune response. This rash typically resolves with treatment. Notify your healthcare provider if a rash appears, as they might recommend stopping the medication.

These precautions ensure safe use of alogliptin (Nesina) and should be discussed with a healthcare provider to address any personal health concerns or conditions.

When taking this medication, some individuals may experience mild side effects such as upper respiratory tract infections, common cold symptoms, or headaches. These effects are generally not severe, but if they persist or cause concern, it's advisable to consult with a healthcare provider. Other potential side effects include constipation, nausea, rash, and diarrhea, which may vary in intensity. Monitoring these symptoms and discussing them with a healthcare provider can be helpful for ongoing management.

There are also more serious side effects to be aware of, though they are rare. Signs of pancreatitis, such as persistent nausea, vomiting, and severe stomach or back pain, require immediate medical attention. Similarly, symptoms of a severe allergic reaction, such as a rash, intense itching, swelling of the face, tongue, or throat, and difficulty breathing, necessitate urgent care.

In some cases, the medication may lead to low blood sugar (hypoglycemia), especially if taken with other diabetes medications. Symptoms such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in hands or feet should be addressed promptly. Carrying glucose tablets or consuming quick sources of sugar can help manage these situations. Conversely, high blood sugar may present as increased thirst or urination, which should also be reported to a healthcare provider for possible adjustments in medication, diet, or exercise.

It’s important to stay vigilant and report any unusual or severe symptoms to a healthcare professional to ensure safe and effective use of this medication.

Beta-blockers, like metoprolol, propranolol, and the glaucoma eye drop timolol, can mask the usual fast or pounding heartbeat you might experience when your blood sugar drops too low (hypoglycemia). However, other signs of low blood sugar, such as dizziness, hunger, or sweating, remain unaffected by these medications. Many drugs can influence your blood sugar levels, complicating their management. Before making any changes to your medication regimen, including starting, stopping, or adjusting a medication, consult your doctor or pharmacist to understand how these changes might impact your blood sugar. Regularly monitor your blood sugar as instructed and report the results to your doctor. If you notice symptoms of high or low blood sugar, inform your doctor immediately as they may need to adjust your diabetes medication, exercise routine, or diet.

Alogliptin (Nesina) can interact with various medications or supplements. Ensure your doctor and pharmacist are aware of all medications and supplements you are taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products. This information is crucial for managing interactions effectively. While this list may not cover all potential interactions with Alogliptin, some medications are noted for their potential to interact. Combining Alogliptin with certain medications, such as antibiotics like ciprofloxacin or other drugs, is generally discouraged unless necessary. If prescribed together, your doctor might adjust dosages or the frequency of use. Additionally, using Alogliptin with certain beta-blockers, like acebutolol or propranolol, might increase the risk of side effects, but could still be the most suitable treatment. In such cases, your doctor will manage dosages accordingly.