Alosetron Coupons & Discount Card - Compare Prices Near You
generic Lotronex
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0.5MG, Alosetron (30 Tablets)
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CVS
$42.60
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Rite Aid
$72.74
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Walmart
$81.63
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Albertsons
$116.39
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Walgreens
$248.03
COUPON PRICEAlosetron savings card
Show this card to your pharmacistCVS
$42.60
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GRP
019876
LH5205459B
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LHX
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Alosetron dosage forms
| Dosage | Quantity | Price from | Per unit |
|---|---|---|---|
| 1MG | 30 Tablets | $72.33 | $2.41 |
| 0.5MG | 30 Tablets | $43.59 | $1.45 |
Alosetron Warnings
Alosetron is a medication that must be used with caution due to the potential for serious and sometimes life-threatening side effects affecting the intestines. It is crucial for patients and healthcare providers to be aware of the associated risks and necessary precautions. Below are key safety warnings and guidelines for the use of alosetron:
Serious Intestinal Risks: Alosetron can cause severe intestinal issues, including reduced blood flow to the large intestine (ischemic colitis) and severe complications from constipation. If you experience constipation, worsening abdominal pain, or bloody diarrhea/stools, stop using the medication immediately and seek medical attention. If constipation persists after discontinuing alosetron, inform your doctor promptly. Do not resume the medication without your doctor's approval.
Patient Selection: This medication is intended for use only by women with severe irritable bowel syndrome (IBS) characterized primarily by diarrhea. Patients must be carefully selected to ensure the benefits outweigh the risks. Discuss with your healthcare provider to understand if alosetron is appropriate for you.
Dosage and Treatment Adjustments: To minimize the risk of constipation, your healthcare provider will prescribe the lowest effective dose of alosetron. If constipation occurs, you may be advised to stop the medication and potentially restart it once the condition improves, or explore alternative treatments.
Contraindications: Alosetron should not be used by individuals with certain pre-existing conditions, including:
- Current or history of severe or chronic constipation
- Intestinal blockages, narrowing, or tears
- Reduced blood flow to the intestines (ischemic colitis)
- Bleeding disorders
- Crohn's disease
- Ulcerative colitis
- Diverticulitis
- Serious liver problems
Drug Interactions: Be cautious if you are taking other medications that may cause constipation, as this can increase the risk of severe side effects.
Emergency Measures: In the event of an overdose or severe side effects, immediate medical intervention is necessary. Always consult your healthcare provider for personalized guidance and communicate any concerns regarding your treatment with alosetron.
This information is intended to ensure safe and informed use of alosetron. Always consult your healthcare provider for more detailed advice tailored to your personal health needs.
Alosetron Side Effects
Common side effects:
- Constipation
- Abdominal discomfort and pain
- Nausea
Less common but important to monitor:
- Bloating
- Heartburn
- Acid reflux
- Hemorrhoids
Serious side effects:
- Ischemic colitis
- Severe constipation
- Serotonin syndrome
- Serious allergic reaction
Alosetron Interactions
Interactions with high risk of serious adverse effects and should be avoided:
- Apomorphine
- Fluvoxamine
- Viloxazine
Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:
- Capmatinib
- Cimetidine
- Ciprofloxacin
- Gatifloxacin
- Givosiran
- Norfloxacin
- Ofloxacin
Interactions with low risk that usually do not require a change in therapy:
What is the drug alosetron used for?
Alosetron is used for the treatment of severe diarrhea-predominant irritable bowel syndrome (IBS) in women who have not responded adequately to conventional therapy.
Why was alosetron taken off the market?
Alosetron was initially taken off the market due to concerns about serious side effects, including severe gastrointestinal complications such as ischemic colitis and severe constipation. These adverse effects posed significant health risks to patients, leading to its withdrawal. However, it was later reintroduced with strict prescribing guidelines and a risk management program to ensure patient safety.
Why is alosetron only for females?
Alosetron is primarily prescribed for females because clinical trials have shown that it is more effective in treating irritable bowel syndrome (IBS) with diarrhea predominantly in women. Additionally, the safety profile and risk-benefit analysis were more favorable in females. As a result, the FDA approved alosetron specifically for women with severe IBS-D who have not responded to conventional therapy.
Who should not take alosetron?
Alosetron should not be taken by individuals with a history of severe constipation, intestinal obstruction, Crohn's disease, ulcerative colitis, diverticulitis, severe hepatic impairment, or a history of ischemic colitis. It is also contraindicated in patients who are unable to understand or comply with the patient-physician agreement required for its use. Additionally, it should not be used by individuals who are allergic to alosetron or any of its components.
What is the best drug for IBS?
The best drug for Irritable Bowel Syndrome (IBS) depends on the individual's specific symptoms and needs. Commonly used medications include antispasmodics like hyoscine for cramping, laxatives for constipation, and loperamide for diarrhea. In some cases, low-dose antidepressants or medications like rifaximin and lubiprostone may be prescribed. It is important for individuals to consult with a healthcare provider to determine the most appropriate treatment for their specific condition.