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Alosetron has been associated with rare but severe, potentially life-threatening side effects affecting the intestines. These include decreased blood flow to the colon (ischemic colitis) and severe constipation complications. It is crucial to discontinue use immediately and seek medical attention if you experience constipation, new or worsening abdominal pain, or bloody stools/diarrhea. Should constipation persist after stopping alosetron, inform your healthcare provider promptly. Refrain from resuming the medication unless instructed by your doctor.

Alosetron is intended only for women with severe diarrhea-predominant irritable bowel syndrome (IBS) and should only be used by carefully selected patients. For more detailed information on the associated risks and benefits, please consult your doctor or pharmacist.

While taking this medication, it's important to be aware of potential side effects, though many individuals experience no serious issues. However, if you encounter severe symptoms like constipation, bloody diarrhea, or increased abdominal pain, seek medical attention immediately.

This medication can occasionally lead to a serious condition known as serotonin syndrome, especially if used with other drugs that elevate serotonin levels. Symptoms to watch for include rapid heartbeat, hallucinations, coordination problems, severe dizziness, nausea, vomiting, diarrhea, muscle twitching, unexplained fever, and unusual agitation. Immediate medical care is crucial if these occur.

Allergic reactions to this drug are rare but can be serious. Seek urgent medical help if you experience symptoms like rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing.

While this list covers some potential side effects, it's not exhaustive. If you notice any other unusual symptoms, consult your healthcare provider for advice.

Keep a comprehensive list of all products you use, including prescription medications, over-the-counter drugs, and herbal supplements, and provide it to both your doctor and pharmacist. One specific drug that can interact with this medication is apomorphine. Additionally, certain medications, such as fluvoxamine and viloxazine, can alter how alosetron is removed from your body, potentially impacting its effectiveness.

Taking other medications that cause constipation can increase the risk of severe constipation complications. Discuss with your doctor or pharmacist to ensure the safe use of all your medications.

The likelihood of experiencing serotonin syndrome or toxicity rises if you're using other drugs that boost serotonin levels. This includes street drugs like MDMA (ecstasy), St. John's wort, and some antidepressants, such as SSRIs (like fluoxetine or paroxetine) and SNRIs (like duloxetine or venlafaxine). The risk may be higher when starting or increasing the dosage of these medications.