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It is crucial to understand the safety information concerning the use of lubiprostone (Amitiza) to prevent potential risks and ensure effective treatment. Please review the following warnings and instructions and consult your healthcare provider with any concerns.

• Low Blood Pressure and Fainting: Lubiprostone may cause a drop in blood pressure shortly after administration, potentially leading to fainting and falls. This is more likely to occur when taking the higher dose (24 mcg) or if you are using other medications that also lower blood pressure. Report any symptoms such as vomiting or diarrhea to your healthcare provider, as these can increase your risk. Should you feel dizzy or as if you might faint, sit or lie down immediately and avoid standing quickly. Contact your healthcare provider to determine if continuing with this medication is safe.

• Breathing Difficulties: Some individuals might experience chest tightness or trouble breathing within 30 to 60 minutes of taking their first dose. These symptoms typically subside after a few hours. If you encounter breathing difficulties, it is important to consult your healthcare provider to assess whether it is safe to continue using lubiprostone, as these symptoms might recur with subsequent doses.

• Intestinal Blockage: Do not use lubiprostone if you have a blockage in your stomach or intestines. Your healthcare provider should evaluate you for any signs of intestinal blockage prior to starting treatment. While taking this medication, inform your provider immediately if you experience symptoms such as abdominal pain, cramping, a sensation of fullness, or difficulty passing gas or stool.

Always follow the advice of your healthcare provider and promptly report any adverse effects or concerns during your treatment with lubiprostone.

When taking this medication, you may experience some common side effects such as nausea and diarrhea, which occur in more than 4% of users. Other mild side effects reported include headache, abdominal pain, bloating, and gas. These effects are generally not serious, but if they persist or worsen, it's advisable to consult your healthcare provider for guidance.

In addition to the common side effects, there are more severe reactions that, while rare, should not be ignored. Serious side effects that require immediate medical attention include severe diarrhea, low blood pressure, fainting, and difficulty breathing. Some individuals may also experience trouble breathing and chest tightness within 30 to 60 minutes after the first dose. Although this reaction typically resolves within a few hours, it is crucial to differentiate it from more severe breathing difficulties or chest pain, which also demand urgent medical care.

Furthermore, an allergic reaction to this medication is very rare, but if you notice symptoms such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing, seek emergency medical assistance right away. If you experience any unusual symptoms not listed here, contacting your healthcare provider is recommended to ensure your safety and well-being.