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Antidepressant medications are commonly prescribed for various conditions such as depression and other mental or mood disorders. These drugs provide significant benefits, including reducing the risk of suicidal thoughts and behaviors. However, research indicates that a small percentage of individuals, particularly those under 25, may experience a deterioration in depression symptoms, other mental or mood issues, or suicidal thoughts or attempts. It is crucial to discuss the advantages and risks of antidepressants with your healthcare provider, especially if you are under 25, regardless of whether the treatment is for a mental or mood disorder.

• Immediately inform your doctor if you notice any signs of worsening depression, changes in psychiatric conditions, or unusual behavioral changes. These may include suicidal thoughts or attempts, increased anxiety, panic attacks, difficulty sleeping, irritability, feelings of hostility or anger, impulsive behaviors, severe restlessness, or very rapid speech.
• Be particularly vigilant for these symptoms when starting a new antidepressant or adjusting the dosage.

Such vigilance is essential to ensure the safe and effective use of antidepressant medications.

You may experience nausea, vomiting, drowsiness, dizziness, loss of appetite, trouble sleeping, weakness, or sweating while taking this medication. These are common side effects and usually not a cause for concern. However, if they persist or worsen, it is important to consult with a healthcare professional.

Some individuals may encounter more serious side effects. Contact a healthcare provider immediately if you experience easy bleeding or bruising, tremors, a decrease in sexual interest or ability, or any other persistent problems.

In rare cases, severe side effects may occur, requiring urgent medical attention. These include fainting, irregular heartbeat, black stools, vomit resembling coffee grounds, seizures, eye pain, swelling, redness, enlarged pupils, or vision changes, such as seeing halos around lights or blurred vision.

There is a rare risk of developing serotonin syndrome, a serious condition that can occur if the medication is combined with other drugs that increase serotonin levels. Symptoms to watch for include a rapid heartbeat, hallucinations, loss of coordination, severe dizziness, nausea, vomiting, diarrhea, muscle twitching, high fever, or unusual agitation.

Men may rarely experience a painful or prolonged erection lasting four hours or more. This requires immediate medical attention to prevent permanent damage.

Though rare, a severe allergic reaction is possible. Seek emergency help if you notice a rash, itching, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing.

This summary does not include all potential side effects. If you notice any other unusual symptoms, contact a healthcare professional for guidance.

Some medications and products can interact with this drug:

1. Bleeding Risk: Medicines that may increase bleeding or bruising, like blood thinners (e.g., dabigatran, warfarin), antiplatelet drugs (e.g., clopidogrel), and NSAIDs (e.g., ibuprofen, naproxen), can interact with this medication. Aspirin also raises bleeding risks when used with this drug. However, if your doctor has prescribed low-dose aspirin (81-162 mg daily) to prevent heart issues, continue taking it unless advised otherwise by your doctor. Consult with your doctor or pharmacist for further guidance.

2. Heart Rhythm Concerns: Certain medications, besides fluvoxamine, can affect heart rhythm, such as pimozide and thioridazine, which may lead to QT prolongation.

3. Drug Removal from the Body: This drug can slow the elimination of some medicines, potentially altering their effectiveness. Examples include alosetron, clozapine, methadone, melatonin, ramelteon, tacrine, tizanidine, vorasidenib, some benzodiazepines (e.g., alprazolam, diazepam, triazolam), and tricyclic antidepressants (e.g., imipramine).

4. MAO Inhibitors: Using MAO inhibitors with this medication can lead to a severe, possibly fatal interaction. Avoid MAO inhibitors (e.g., isocarboxazid, linezolid, methylene blue, phenelzine, selegiline) during and for two weeks before and after treatment with this drug. Discuss with your doctor when to start or stop these medications.

5. Serotonin Syndrome Risk: The risk of serotonin syndrome increases when combined with drugs that raise serotonin levels. These include some antidepressants (like SSRIs and SNRIs), street drugs (such as MDMA), St. John's wort, and tryptophan. Be cautious when starting or adjusting doses of these medications.

6. Caffeine Interaction: This medication may heighten the effects of caffeine. It's advisable to limit caffeine intake from drinks like coffee, tea, colas, and chocolate, as well as nonprescription products containing caffeine.

7. Drowsiness: Notify your doctor if you're using products causing drowsiness, including alcohol, marijuana, antihistamines (e.g., cetirizine, diphenhydramine), sleep or anxiety medications (e.g., alprazolam, zolpidem), muscle relaxants, and opioids (e.g., codeine). Check medicine labels for ingredients that can cause drowsiness and consult your pharmacist about safe usage.

8. Smoking: Smoking reduces blood levels of this medication. Inform your doctor if you smoke or have recently quit.

9. Lab Test Interference: This drug might interfere with certain lab tests, like brain scans for Parkinson's disease, potentially causing inaccurate results. Ensure all medical personnel are aware of your medication use.