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Fluvoxamine is an antidepressant medication used to treat various mental health conditions. However, it carries certain risks and requires careful consideration before use. Below are the key safety information and warnings associated with this medication:

• Suicidal Thoughts and Behavior: There is an increased risk of suicidal thoughts or behavior, particularly in individuals under 25 years of age. It's crucial to monitor for any new or worsening symptoms of depression, suicidal thoughts, or behavioral changes, especially during the initial months of treatment or when dosage changes occur. Immediate communication with your healthcare provider is necessary if such symptoms arise.

• Serotonin Syndrome: This is a rare but serious condition caused by excessive levels of serotonin in the body. The risk increases if fluvoxamine is combined with other medications affecting serotonin levels, such as other antidepressants, lithium, or St. John's wort. Symptoms include rapid heart rate, sweating, muscle stiffness, fever, and confusion. Seek medical attention immediately if these occur.

• Medication Interactions: Fluvoxamine can interact with other medications, potentially leading to severe heart problems. Inform your healthcare provider and pharmacist of all medications you're taking to avoid dangerous interactions, particularly if you are also taking thioridazine, tizanidine, or benzodiazepines.

• Glaucoma: Antidepressants like fluvoxamine may exacerbate eye conditions, specifically narrow-angle glaucoma. If you experience vision changes, consult your healthcare or eye care professional promptly.

• Withdrawal Symptoms: Abrupt discontinuation of fluvoxamine can lead to withdrawal symptoms such as nausea, anxiety, and dizziness. Always follow your healthcare provider's guidance when discontinuing this medication.

• Bleeding Risk: Fluvoxamine can increase the risk of bleeding, especially when taken with aspirin, NSAIDs, or blood thinners. Report any unusual bruising or bleeding, and consult your provider for possible dose adjustments if you're on blood thinners.

• Mania: For those with bipolar disorder, fluvoxamine may trigger manic episodes. Discuss any personal or family history of bipolar disorder with your provider before starting the medication.

• Seizures: Fluvoxamine may cause seizures, although this is rare. Notify your healthcare provider if you have a history of seizures.

• Low Sodium Levels: In rare cases, fluvoxamine can lead to low sodium levels in the blood. Older adults and those on diuretics are at higher risk. Report symptoms like confusion, headache, or memory issues to your healthcare provider.

• Sexual Problems: Fluvoxamine, as an SSRI, can cause sexual side effects, including decreased libido and difficulty achieving orgasm. Discuss these issues with your provider for possible management strategies.

Contraindications include the use of certain medications such as tizanidine and thioridazine, and the recent use of MAOIs. If any of these apply to you, consult your healthcare provider before taking fluvoxamine. Always discuss potential risks and benefits with your healthcare provider to ensure safe use of fluvoxamine.

Common side effects:

• Nausea
• Dizziness
• Drowsiness
• Trouble sleeping
• Weakness
• Sweating
• Dry mouth
• Headaches
• Nervousness
• Diarrhea
• Constipation
• Upset stomach
• Loss of appetite

Less common but important to monitor:

• Easy bleeding or bruising
• Shaking or tremors
• Decreased interest in sex
• Changes in sexual ability
• Symptoms of serotonin syndrome (such as fast heartbeat, hallucinations, and severe dizziness)

Serious side effects:

• Fainting
• Irregular heartbeat
• Black stools
• Vomit resembling coffee grounds
• Seizures
• Eye pain or swelling
• Widened pupils
• Vision changes
• Painful or prolonged erection lasting four or more hours
• Serious allergic reaction (symptoms like rash, swelling of the face or throat, severe dizziness, and breathing difficulties)

Interactions with high risk of serious adverse effects and should be avoided:

• Agomelatine
• Alosetron
• Astemizole
• Cisapride
• Methylene Blue
• Moclobemide
• Pimozide
• Thioridazine
• Tizanidine
• MAO inhibitors (such as isocarboxazid, Linezolid, phenelzine, Selegiline, Tranylcypromine)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Clopidogrel
• Ibuprofen
• Naproxen
• Warfarin
• Fluoxetine
• Duloxetine
• Alprazolam
• Methadone
• Melatonin
• Caffeine

Interactions with low risk that usually do not require a change in therapy:

• MDMA
• St. John's wort
• Tryptophan