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This medication has specific safety warnings and usage instructions to ensure its safe and effective use. Please review the following information carefully and discuss any concerns with your healthcare provider.

• Risk of Worsening Blood Flow: Alphagan P (brimonidine) may slightly increase the risk of reduced blood flow or lower blood pressure. This can be particularly concerning for individuals with existing conditions such as low blood flow to the brain or heart, Raynaud's phenomenon, orthostatic hypotension, blood vessel disorders, or serious heart issues. It is advisable to consult your healthcare provider if you have any of these conditions before beginning treatment.

• Risk of Eye Infections: The use of Alphagan P (brimonidine) may lead to bacterial keratitis, an infection of the cornea. This risk increases if the eyedrop bottle becomes contaminated. To minimize this risk, always wash your hands before use and avoid contact between the dropper tip and any surfaces, including your eye or hands.

• Contact Lens Precaution: The preservative benzalkonium chloride in Alphagan P (brimonidine) can be absorbed by soft contact lenses, potentially causing damage. If you wear soft contacts, remove them prior to applying the eyedrops and wait at least 15 minutes before reinserting them.

• Proper Application: Alphagan P (brimonidine) is intended for use on the surface of the eye only. Do not ingest or inject this medication, as the safety of such use has not been established and may be dangerous.

• Contraindications: This medication is not suitable for use in children under the age of 2. If this condition applies to you, seek guidance from your healthcare provider before using this medication.

When using this medication, some people might experience common side effects such as dry mouth, red or itchy eyes, eye burning or stinging, headaches, blurry vision, and sleepiness. These effects, though typically mild, should be monitored. If they persist or worsen, it is advisable to consult a healthcare provider for guidance. Additionally, some individuals may feel as if there's something in their eye, or notice small white patches inside the eyelids, indicative of an allergic reaction in the eye.

Less commonly, users could experience symptoms like eye irritation, tearing, red or swollen eyelids, dizziness, flu-like symptoms, or stomach upset. There may be changes in vision, such as abnormal or blurred vision, and other symptoms like weakness or muscle pain. Occasionally, the medication may cause color change or thinning of the cornea, sensitivity to light, and pale or white eyelids. If any of these symptoms are severe, it's important to contact a healthcare provider.

Rare but serious side effects requiring immediate medical attention include persistent headaches, fast or irregular heartbeats, eye pain or swelling, and extreme sensitivity to light. Allergic reactions, though uncommon, can be severe and may present as rash, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Immediate medical help is crucial if these occur. Always inform a healthcare provider about any new or worsening symptoms for appropriate management.

When taking Alphagan P (Brimonidine), it's important to be aware of potential interactions with other medications. This medication may interact with several drugs, including beta-blockers like Atenolol and metoprolol, Digoxin, and medications for high blood pressure such as Clonidine and Terazosin. Tricyclic antidepressants like Amitriptyline can also interact with Alphagan P.

Additionally, if you are using substances that can cause drowsiness, such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine), you should inform your doctor or pharmacist. These can increase the sedative effects of Alphagan P.

It's also advised to check the labels of all your medications, including over-the-counter drugs like allergy or cough-and-cold products, as they may contain ingredients that contribute to drowsiness. Consult your pharmacist to ensure safe use of these products.

Lastly, using Alphagan P with Iobenguane I 131 is generally not recommended unless necessary. If both are prescribed, your doctor may adjust the dosage or frequency of one or both medications. Always keep your healthcare providers informed about all the medicines and supplements you are taking.