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The following safety information outlines critical warnings associated with the use of this medication. It is important to review these points and discuss any concerns with your healthcare provider to ensure safe use of the medication.

• Limited Oral Absorption Risk: The absorption of atovaquone (Mepron) is significantly influenced by food intake. Taking the medication on an empty stomach can lead to insufficient absorption, which may result in treatment failure. This is particularly concerning for individuals who have difficulty eating or those with digestive disorders.

• Liver Toxicity: There is a potential for atovaquone (Mepron) to cause or exacerbate liver problems. If you have a history of liver disease, it is crucial to inform your healthcare provider. They will need to monitor your liver function closely during treatment to prevent any complications.

Please ensure to follow these guidelines carefully and maintain communication with your healthcare provider throughout your treatment.

Common side effects:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness
• Trouble sleeping
• Runny nose

Less common but important to monitor:

• Mild rash
• Fever

Serious side effects:

• Severe allergic reaction (rash, itching or swelling of the face, tongue, or throat, severe dizziness, and trouble breathing)
• Liver problems (persistent nausea or vomiting, loss of appetite, stomach or abdominal pain, yellowing of the eyes or skin, and dark urine)

Interactions with high risk of serious adverse effects and should be avoided:

• Efavirenz
• Rifabutin
• Rifampin
• Ritonavir

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Tetracycline
• Warfarin

Interactions with low risk that usually do not require a change in therapy:

• Metoclopramide