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This safety information outlines crucial warnings and precautions associated with the use of erythromycin. It is important to thoroughly review these details and discuss any concerns with your healthcare provider.

• Liver Damage: Erythromycin may lead to severe or potentially life-threatening liver damage, especially if you have a history of liver problems. If you experience symptoms such as unexplained abdominal pain, nausea, vomiting, dark urine, pale stools, or yellowing of the skin or eyes, seek medical attention immediately. Regular blood tests may be necessary to monitor liver health.

• Heart Rhythm Changes (QT Prolongation): Erythromycin can rarely cause a serious heart rhythm condition known as QT prolongation, which may result in cardiac arrest and potentially be fatal. Those over 65 or with heart conditions are at greater risk. Avoid erythromycin if you are on medications that also prolong the QT interval. Inform your healthcare provider of any heart issues and all current medications, including over-the-counter drugs, vitamins, and supplements.

• Syphilis in Infants: Erythromycin may be ineffective in preventing congenital syphilis when used during pregnancy. Notify your healthcare provider if you were treated with erythromycin for syphilis while pregnant. Your newborn may require additional antibiotic treatment.

• Severe Diarrhea: This antibiotic increases the risk of Clostridioides difficile-associated diarrhea (CDAD), a potentially life-threatening condition. If you experience bloody or watery stools, stop taking erythromycin and contact your healthcare provider immediately. Higher risk factors include using multiple antibiotics, long-term antibiotic use, age over 65, recent hospitalization, and a weakened immune system.

• Drug Interactions: Erythromycin interacts with various drugs, some interactions can be life-threatening. Avoid using it with other medications that affect heart rhythm.

• Worsening Myasthenia Gravis: Erythromycin may exacerbate symptoms in individuals with myasthenia gravis, such as muscle weakness and breathing difficulties. Discuss any concerns with your healthcare provider.

• Intestinal Blockage in Infants: Prolonged use of erythromycin in infants can lead to an intestinal blockage. This medication is typically reserved for life-threatening conditions in infants. If prescribed, monitor for signs of vomiting or fussiness during feeding and consult your child's healthcare provider promptly.

Contraindications: Avoid using erythromycin if you are taking any of the following: terfenadine, astemizole, pimozide, cisapride, ergotamine, dihydroergotamine, lovastatin, or simvastatin (Zocor). Consult your healthcare provider to discuss alternative treatments if these apply to you.

When taking this medication, some common side effects you may experience include nausea, vomiting, diarrhea, stomach pain or cramping, and loss of appetite. These effects are generally mild and can often be minimized by taking the medication with food. However, if they persist or worsen, it's important to consult your healthcare provider.

Although many users do not experience serious side effects, there are some that require immediate medical attention. These include signs of liver damage such as persistent nausea and vomiting, yellowing of the eyes or skin, dark urine, and severe abdominal pain. If you notice any unusual tiredness, muscle weakness, trouble speaking, blurred vision, drooping eyelids, or hearing loss, alert your doctor promptly.

Rare but severe side effects include a serious intestinal condition linked to C. difficile bacteria, which may present as persistent diarrhea, abdominal pain, or blood in the stool. In such cases, avoid using anti-diarrhea or opioid products and contact your doctor immediately. Additionally, watch for signs of a severe allergic reaction, such as rash, swelling of the face or throat, severe dizziness, or trouble breathing, and seek urgent medical help if these occur.

Prolonged use of this medication may lead to oral thrush or a new yeast infection, particularly if you notice white patches in your mouth or changes in vaginal discharge. While these occurrences are unusual, it’s essential to remain vigilant and report any unexpected symptoms to your healthcare provider right away.

Erythromycin can interact with various medications, impacting how it and other drugs perform. It's important to inform your doctor or pharmacist about all medications and supplements you're currently using, whether prescribed, over-the-counter, or herbal.

Some drugs should not be combined with erythromycin because they can lead to severe interactions. These include astemizole, bepridil, cisapride, colchicine, dihydroergotamine, dronedarone, and others like lovastatin and simvastatin. These interactions may affect heart rhythm or how these drugs are processed in your body.

Additionally, erythromycin can alter the effectiveness of certain medications by affecting their removal from the body. This includes drugs like bromocriptine, certain benzodiazepines, and some ED or pulmonary hypertension treatments, such as sildenafil and tadalafil.

In some cases, using erythromycin with other medications might require dose adjustments. Examples include amiodarone, diltiazem, digoxin, carbamazepine, and verapamil, among others. These interactions could potentially lead to increased side effects or reduced efficacy.

Lastly, erythromycin may interfere with specific lab tests, such as urine tests, potentially causing inaccurate results. Ensure all healthcare providers are aware you're taking erythromycin to avoid misinterpretation of test results.