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The following information outlines critical safety considerations and warnings for the use of this medication. It is essential to read these details thoroughly and seek advice from your healthcare provider if you have any questions or concerns.

• Skin Irritation: Tretinoin may lead to redness, dryness, pain, and irritation at the application site. It is advised not to use the medication on sunburned skin or areas affected by eczema as these are more susceptible to irritation. Individuals with sensitive skin, eczema, or those exposed to extreme weather conditions should exercise caution.

• Sun Sensitivity: Tretinoin increases the skin's sensitivity to sunlight, both natural and artificial, such as from sunlamps. This heightened sensitivity can result in easier sunburn, potentially increasing the risk of premature skin aging and skin cancer. Individuals with high sun exposure, those whose skin burns easily, or who live in hot climates and work outdoors should take extra precautions.

• Fish Allergy Caution (specific to Atralin gel and generics): Certain tretinoin products, like Atralin gel and its generic versions, contain fish proteins. If you have a fish allergy, use this medication with caution. Should you experience a red, itchy rash (hives), discontinue use and inform your healthcare provider, as you may need to stop using tretinoin.

Please note that there are no specific contraindications listed for this medication. Always follow your healthcare provider's guidance when using tretinoin.

When using this medication, some individuals may experience common side effects such as dry skin, peeling or flaky skin, a burning sensation, redness, itching, and skin pain. These reactions are generally mild and often resolve on their own. However, if they persist or become bothersome, it is advisable to consult a healthcare provider. Additionally, sunburns can occur, so it is important to take precautions when exposed to sunlight.

There are also other side effects reported by some users, including the development of blisters, crusted skin, and changes in skin color. While these effects are less common, monitoring their progression is important, and medical advice should be sought if they occur.

Rare but serious side effects include severe allergic reactions characterized by itchy, red rashes (hives), difficulty breathing, chest tightness, or swelling of the lips, tongue, face, or eyes. These symptoms are serious and require immediate medical attention to ensure safety and proper care.