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When using bexarotene, it is crucial to follow specific precautions to prevent harm, especially concerning pregnancy. Below are the key safety and warning details:

• Pregnancy Risk: Bexarotene can cause serious birth defects. Women who are pregnant must not use this medication. If you become pregnant while taking bexarotene, inform your healthcare provider immediately.

• Birth Control Measures: Before starting bexarotene, and every month during treatment, women should undergo a pregnancy test and receive counseling on birth control methods. It is essential to use two reliable forms of birth control starting one month before beginning treatment, throughout the treatment period, and for one month after stopping the medication. At least one method should be non-hormonal, such as condoms, a cervical cap, diaphragm, copper coil IUD, or spermicide. Alternatively, abstain from sexual activity to prevent pregnancy.

• Precautions for Males: Men taking bexarotene should use condoms during sexual intercourse with a partner who is or could become pregnant. This precaution should continue until one month after the last dose.

By adhering to these guidelines, you can help minimize the potential risks associated with bexarotene. Always consult your healthcare provider for further advice and information.

Bexarotene may cause some common side effects such as headaches, tiredness, nausea, vomiting, dry skin, diarrhea, and trouble sleeping. These effects are generally mild but should be reported to a healthcare professional if they persist or worsen. The medication can also impact cholesterol levels, potentially increasing "bad" fats in the blood. Regular blood tests are essential to monitor these levels, and adjustments to medication may be necessary if they rise.

An underactive thyroid, or hypothyroidism, is a possible side effect of bexarotene. Symptoms to be aware of include unusual weight gain, feeling cold, constipation, slow heartbeat, and low energy. These symptoms should be reported promptly for further evaluation and possible treatment. Serious side effects that require immediate medical attention include swelling of the hands or feet, muscle pain, a fast or pounding heartbeat, mental changes like depression or anxiety, persistent nausea or vomiting, stomach pain, dark urine, vision changes, and yellowing eyes or skin.

Bexarotene can also lower the body's immune response, increasing infection risk. Signs of infection, such as a persistent sore throat, fever, or chills, should be reported without delay. Although rare, severe allergic reactions may occur, characterized by rash, itching, swelling, dizziness, and breathing difficulties. Immediate medical assistance is crucial in such cases. While this is not an exhaustive list of side effects, any unusual symptoms should be discussed with a healthcare provider.

Targretin (Bexarotene) can interact with various medications and supplements. It's important to inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescribed, over-the-counter, vitamins, or herbal products.

Potential Interactions:

• Hormonal Birth Control: Targretin may reduce the effectiveness of hormonal contraceptives such as pills, patches, or rings, which could lead to pregnancy. It’s advisable to discuss reliable backup birth control methods with your doctor or pharmacist. Pay attention to any new spotting or breakthrough bleeding, as these could indicate that your birth control is not working effectively.

• Interacting Medications: Avoid using Targretin with medications such as Gemfibrozil or Tamoxifen unless specifically advised by your doctor. If these are prescribed together, your doctor might adjust the dosage or frequency.

• Increased Side Effect Risks: When used with drugs like Atorvastatin, Erythromycin, and others, Targretin might increase the risk of side effects. Your doctor may alter doses or usage as necessary.

• Lab Test Interference: Targretin can interfere with certain laboratory tests, including CA-125 levels, potentially leading to inaccurate results. Ensure that all healthcare providers and lab personnel are aware that you are using this medication.

Always have a thorough discussion with your healthcare provider about possible interactions and follow their guidance closely.