Bexarotene

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bexarotene

Bexarotene, marketed as Targretin, is a topical gel specifically used to address skin issues associated with a rare cancer called cutaneous T-cell lymphoma (CTCL). This medication is generally recommended for patients whose condition persists or recurs despite trying other treatments. Bexarotene is classified as a retinoid, a derivative of vitamin A, which functions by inhibiting the growth and proliferation of cancer cells. Although the precise mechanism by which it treats CTCL is not fully understood, its ability to slow or stop cancer cell progression is well-documented. Always consult with your healthcare provider before starting any new treatment to ensure it is safe and appropriate for your situation.
Our Targretin coupons are free to use. You can print the coupon, email it to yourself, or receive the Targretin coupon via text message. To get your free discount, show the pharmacist your Targretin savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Targretin prices will update based on your prescription needs. Above our Targretin coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Targretin savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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75MG, Bexarotene (30 Capsules)

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Rite Aid

$171.57

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Walgreens

$1751.15

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Albertsons

$2136.28

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Rite Aid

$171.57

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Targretin dosage forms

The average cost for 30 Capsules of Targretin (bexarotene) at 75MG is $171.07 with a free coupon. This is 2.12% off the average retail price of $8050.5
DosageQuantityPrice fromPer unit
75MG30 Capsules$171.07$5.7

Targretin Warnings

When using bexarotene, it is crucial to follow specific precautions to prevent harm, especially concerning pregnancy. Below are the key safety and warning details:

  • Pregnancy Risk: Bexarotene can cause serious birth defects. Women who are pregnant must not use this medication. If you become pregnant while taking bexarotene, inform your healthcare provider immediately.

  • Birth Control Measures: Before starting bexarotene, and every month during treatment, women should undergo a pregnancy test and receive counseling on birth control methods. It is essential to use two reliable forms of birth control starting one month before beginning treatment, throughout the treatment period, and for one month after stopping the medication. At least one method should be non-hormonal, such as condoms, a cervical cap, diaphragm, copper coil IUD, or spermicide. Alternatively, abstain from sexual activity to prevent pregnancy.

  • Precautions for Males: Men taking bexarotene should use condoms during sexual intercourse with a partner who is or could become pregnant. This precaution should continue until one month after the last dose.

By adhering to these guidelines, you can help minimize the potential risks associated with bexarotene. Always consult your healthcare provider for further advice and information.

Targretin Side Effects

Pain, redness, irritation, itching, or flaking of the skin may occur at the application site. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Bexarotene can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Targretin Interactions

Targretin (bexarotene) can interact with various medications and supplements. It's important to inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescribed, over-the-counter, vitamins, or herbal products.

Potential Interactions:

  • Hormonal Birth Control: Targretin may reduce the effectiveness of hormonal contraceptives such as pills, patches, or rings, which could lead to pregnancy. It’s advisable to discuss reliable backup birth control methods with your doctor or pharmacist. Pay attention to any new spotting or breakthrough bleeding, as these could indicate that your birth control is not working effectively.

  • Interacting Medications: Avoid using Targretin with medications such as gemfibrozil or tamoxifen unless specifically advised by your doctor. If these are prescribed together, your doctor might adjust the dosage or frequency.

  • Increased Side Effect Risks: When used with drugs like atorvastatin, erythromycin, and others, Targretin might increase the risk of side effects. Your doctor may alter doses or usage as necessary.

  • Lab Test Interference: Targretin can interfere with certain laboratory tests, including CA-125 levels, potentially leading to inaccurate results. Ensure that all healthcare providers and lab personnel are aware that you are using this medication.

Always have a thorough discussion with your healthcare provider about possible interactions and follow their guidance closely.

Targretin FAQs
What is Targretin used for?

Targretin is used for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have not responded well to other systemic therapies.

Bexarotene is not classified as traditional chemotherapy. It is a retinoid, which is a type of medication related to vitamin A, and is used primarily to treat cutaneous T-cell lymphoma.

When taking bexarotene, it is advisable to avoid grapefruit and grapefruit juice. Grapefruit can interfere with the metabolism of the medication, potentially leading to increased levels in the blood and a higher risk of side effects. It is also important to follow any specific dietary recommendations provided by a healthcare provider.

Targretin (bexarotene) is considered effective for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. Its effectiveness can vary among individuals, and it is typically evaluated based on the reduction of skin lesions and improvement in symptoms. Clinical trials have shown that a significant number of patients experience a partial or complete response to the treatment. However, the effectiveness can depend on various factors, including the stage of the disease and the patient's overall health. It is important for patients to discuss their specific case with their healthcare provider to understand how Targretin may work for them.

Targretin (bexarotene) works by selectively binding to and activating retinoid X receptors (RXRs). These receptors are involved in regulating gene expression that controls cell growth, differentiation, and apoptosis. By activating RXRs, Targretin can inhibit the growth of certain cancer cells, particularly in cutaneous T-cell lymphoma (CTCL).

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