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The following safety information provides essential guidance on the potential risks and necessary precautions associated with the use of methylprednisolone (Medrol). Please review these details and consult your healthcare provider if you have any concerns.

• Infection Risks: Long-term use of methylprednisolone (Medrol) can increase susceptibility to infections or mask their symptoms, including serious fungal, viral (e.g., chickenpox, measles), or bacterial (e.g., tuberculosis) infections. Avoid close contact with anyone with a history of these infections. Inform your provider if you have a history of TB or parasitic infections for proper monitoring. Consult your provider before receiving any vaccinations, especially live vaccines, as these may pose increased infection risks during treatment.

• Mood and Behavioral Changes: This medication may cause mood swings, depression, anxiety, trouble sleeping, or hallucinations. Contact your provider immediately if you experience any of these symptoms. Individuals with a history of mental health conditions should be particularly cautious.

• Adrenal Gland Function: Long-term use can lead to adrenal suppression, where the adrenal glands reduce hormone production. Do not abruptly stop taking the medication without professional advice. Symptoms of withdrawal in adults include fever, joint pain, and low energy; in children, symptoms may include slowed growth, weight gain, and headaches. Your provider will aim to prescribe the lowest effective dose and may recommend tests to monitor adrenal function.

• Heart and Kidney Implications: The medication can alter fluid and electrolyte balance, potentially causing high blood pressure, swelling, and kidney issues. It may also harm the heart post-heart attack. Notify your provider if you have a history of heart failure, high blood pressure, or kidney problems.

• Stomach Issues: Methylprednisolone (Medrol) can increase the risk of stomach irritation, ulcers, and bleeding, particularly if combined with NSAIDs or alcohol. Seek immediate medical help for persistent stomach pain or bloody stools. Individuals with a history of stomach bleeding, ulcers, or ulcerative colitis should exercise caution.

• Bone Health: Extended use can impair calcium absorption, weakening bones and potentially leading to osteoporosis in adults or growth delays in children. Discuss your risk with your provider, especially if you have a history of fractures or osteoporosis.

• Eye Health: Long-term use increases the risk of cataracts, glaucoma, and certain eye infections. Report any vision changes, eye pain, or blurry vision to your provider. Regular eye exams may be necessary during extended treatment.

• Blood Sugar Levels: Prolonged use can elevate blood sugar levels, possibly leading to diabetes. Alert your provider if you experience symptoms such as confusion, excessive thirst, frequent urination, or fruity-smelling breath. Diabetics may need to monitor blood sugar levels closely.

Contraindications: Use of methylprednisolone (Medrol) is contraindicated for individuals currently with a fungal infection or those receiving live vaccines while on high doses of the medication. Please consult your healthcare provider if these conditions apply to you.

Common side effects:

• Nausea
• Vomiting
• Heartburn
• Headache
• Dizziness
• Trouble sleeping
• Increased appetite
• Acne
• Increased sweating

Less common but important to monitor:

• Unusual weight gain
• Changes in menstrual periods
• Bone or joint pain
• Easy bruising or bleeding
• Mood changes such as depression or agitation
• Muscle weakness or pain
• Swelling of the face, ankles, or hands
• Thinning skin
• Unusual hair or skin growth
• Vision problems
• Irregular heartbeat
• Stomach or intestinal bleeding

Serious side effects:

• Seizures
• Severe allergic reactions
• Severe dizziness
• Breathing difficulties
• Increased susceptibility to serious infections
• Elevated blood sugar levels in diabetics

Interactions with high risk of serious adverse effects and should be avoided:

• Desmopressin
• Rotavirus Vaccine, Live

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aceclofenac
• Acemetacin
• Aldesleukin
• Amtolmetin Guacil
• Balofloxacin
• Bemiparin
• Besifloxacin
• Bromfenac
• Bufexamac
• Celecoxib
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Dipyrone
• Droxicam
• Enoxacin
• Etodolac
• Etoricoxib
• Fenoprofen
• Flurbiprofen
• Ibuprofen
• Indomethacin
• Ketoprofen
• Ketorolac
• Lornoxicam
• Meloxicam
• Naproxen
• Nimesulide
• Piroxicam
• Ritonavir
• Rofecoxib
• Sulindac
• Telaprevir
• Tenoxicam
• Warfarin

Interactions with low risk that usually do not require a change in therapy:

• Aspirin
• Erythromycin
• Ketoconazole
• Phenobarbital
• Phenytoin