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The following information outlines critical safety considerations associated with the use of Bevespi Aerosphere (glycopyrrolate / formoterol). It is essential to review these details carefully and discuss any concerns with your healthcare provider.

• Not for Acute COPD Episodes: Bevespi Aerosphere is not intended for use during sudden worsening of COPD symptoms, such as increased coughing or difficulty breathing. It is not a rescue inhaler. Consult your healthcare provider if symptoms persist or worsen.

• Bronchospasm Risk: Inhalation of this medication can occasionally cause bronchospasm, leading to breathing difficulties, wheezing, or chest discomfort. If you experience difficulty breathing after using Bevespi, use a rescue inhaler and seek medical attention immediately.

• Severe Allergic Reactions: There is a potential for severe allergic reactions, including anaphylaxis, characterized by symptoms such as facial swelling, rash, or difficulty breathing. Seek emergency medical help if these symptoms occur.

• Cardiovascular Concerns: Formoterol may increase blood pressure and heart rate, or alter heart rhythms. These effects are rare if taken as prescribed. Regular monitoring of heart rate and blood pressure is advisable for those with pre-existing heart conditions. Inform your provider if you experience dizziness, rapid heartbeat, or tremors.

• Ocular Risks: Bevespi Aerosphere may increase eye pressure and exacerbate glaucoma. Avoid spraying the medication in the eyes and consult an eye specialist if you notice any changes in vision.

• Urinary Difficulty: Those with prostate problems should use this medication with caution, as it may exacerbate urination difficulties. Contact your healthcare provider if you experience this issue.

• Hypokalemia: Excessive use of Bevespi Aerosphere can lead to low potassium levels, which are usually mild but can cause symptoms like muscle cramps or a racing heart. Report these symptoms to your healthcare provider.

Contraindications:

• Do not use Bevespi Aerosphere for sudden shortness of breath or asthma attacks.
• Avoid use if allergic to glycopyrrolate or formoterol.

Always consult your healthcare provider to ensure this medication is appropriate for your condition and to discuss any potential interactions with other drugs or substances.

When taking this medication, it's important to be aware of potential side effects, ranging from mild to severe. Common side effects include a cough and urinary tract infections, which are typically mild. If these persist or become bothersome, consult your healthcare provider for advice. Other side effects that have been reported include chest pain, headaches, dizziness, and dry mouth. While these are generally not severe, you should reach out to your healthcare provider if they occur.

There are also more serious side effects, although they are rare. These include significant allergic reactions, which might manifest as hives, facial swelling, or difficulty breathing. If you experience sudden severe wheezing or trouble breathing, use your quick-relief inhaler and seek medical help immediately. Additionally, be vigilant for any signs of heart-related issues such as chest pain, irregular heartbeat, severe dizziness, or fainting, as these require urgent medical attention.

Monitor your blood pressure regularly, as this medication may cause an increase. Report high readings to your healthcare provider. If you notice symptoms like muscle cramps, increased thirst or urination, or any vision changes, contact your healthcare provider immediately. Always remember, this is not an exhaustive list of side effects. If you experience any other symptoms, it's important to consult with your healthcare provider.