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The following information outlines essential safety concerns and precautions related to the use of Briviact (brivaracetam). It is important to review these carefully and discuss any questions or concerns with your healthcare provider.

• Suicidal Thoughts or Behavior: Brivaracetam, like other antiepileptic drugs, may increase the risk of suicidal thoughts or behavior. Be vigilant for any signs of new or worsening depression or significant mood changes, particularly in the initial months of treatment. Contact your healthcare provider immediately if you notice such changes. In cases of suicidal thoughts, seek emergency assistance by calling 911 or visiting a medical facility promptly.

• Drowsiness and Coordination Issues: This medication may cause drowsiness, fatigue, dizziness, or difficulty with movement and balance. These effects are most likely when starting the medication but can occur at any time during treatment. Avoid activities that require full alertness, such as driving or operating heavy machinery, until you understand how brivaracetam affects you.

• Abnormal Mood and Behavior: Brivaracetam can lead to changes in mood, thoughts, or behavior. Patients may experience irritability, aggression, anxiety, mood swings, depression, withdrawal, hallucinations, paranoia, or psychotic behavior. Report any such changes to your healthcare provider immediately.

• Severe Allergic Reactions: Some individuals may experience severe allergic reactions, including angioedema (swelling of the face, mouth, or throat) and airway constriction, which can impede breathing. If you experience these symptoms, discontinue use and seek immediate medical attention.

• Withdrawal Seizures: Do not abruptly discontinue brivaracetam without consulting your healthcare provider, as this may lead to withdrawal seizures. Your provider will guide you on how to safely taper off the medication if necessary, by gradually reducing the dose over time.

Please remember these guidelines to ensure safe and effective use of Briviact (brivaracetam). Always consult your healthcare provider for personalized advice and support.

Briviact (brivaracetam) is an antiepileptic medication used to manage partial-onset seizures. When taking Briviact, it's important to be aware of potential interactions with other substances, as these can affect the drug's effectiveness or increase the risk of side effects.

Interactions with Other Medications:

• Rifampin: This antibiotic can decrease Briviact levels in the blood, potentially reducing its effectiveness. To compensate, your doctor may recommend doubling the Briviact dosage during rifampin treatment.

• Carbamazepine: Used to treat seizures and nerve pain, carbamazepine can interact with Briviact, leading to increased levels of carbamazepine's active metabolite. While this doesn't typically cause safety concerns, if you experience side effects, your doctor might adjust the carbamazepine dosage.

• Phenytoin: Another seizure medication, phenytoin levels may rise when taken with Briviact. It's advisable to monitor phenytoin levels if you're starting or stopping Briviact to ensure they remain within a safe range.

• Levetiracetam: Combining Briviact with levetiracetam doesn't provide additional benefits and may not be recommended.

Interactions with Herbal Supplements:

• St. John's Wort: This herbal remedy can lower Briviact levels in the body, potentially making it less effective. It's best to avoid St. John's Wort while on Briviact therapy.

Alcohol Interaction:

Consuming alcohol during Briviact treatment can enhance alcohol's effects on attention, memory, and motor skills. To avoid increased drowsiness and coordination issues, it's recommended to limit or avoid alcohol intake while taking Briviact.

General Recommendations:

Always inform your healthcare provider about all medications, supplements, and herbal products you're using before starting Briviact. This ensures they can manage potential interactions effectively. If you experience any unusual symptoms or side effects, contact your doctor promptly.