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The following safety information outlines important warnings associated with the use of pregabalin ER (Lyrica CR). It is crucial to understand these risks and take necessary precautions. Always discuss any concerns with your healthcare provider.

• Severe Allergic Reactions and Angioedema: Pregabalin ER (Lyrica CR) can cause severe allergic reactions, including life-threatening symptoms like facial swelling and anaphylaxis. It may also lead to angioedema, characterized by swelling of the face, throat, and tongue, particularly if you are using ACE inhibitors (e.g., lisinopril). Seek immediate medical help if these symptoms occur.

• Suicidal Thoughts and Behavior: There is a rare risk of increased suicidal thoughts or behavior with antiepileptic drugs like pregabalin ER. Regular screening for depression and suicidal ideation by your healthcare team is advised. Contact your healthcare provider immediately if you experience symptoms such as depression, anxiety, or unusual mood changes.

• Dangerously Slow Breathing (Respiratory Depression): Pregabalin ER can cause respiratory depression, especially in individuals with lung conditions or those taking depressant medications or alcohol. Signs include excessive drowsiness, fatigue, and shallow breathing. Immediate medical attention is necessary if these symptoms develop.

• Withdrawal Symptoms: Abrupt cessation of pregabalin ER may lead to withdrawal symptoms like nausea, headache, insomnia, anxiety, and diarrhea. Consult your prescriber before altering your medication regimen to ensure a safe tapering process.

• Difficulty Concentrating, Sleepiness, and Dizziness: This medication may cause dizziness or drowsiness, affecting your concentration and reaction times. The risk increases if combined with other sedative medications. Avoid driving or activities requiring full alertness until you understand how the drug affects you.

• Swelling of Hands and Feet: There is a possibility of fluid retention leading to swelling in the extremities, particularly if you have heart failure or are taking glitazone medications for diabetes. Persistent swelling should be evaluated by your healthcare provider to prevent exacerbation of heart conditions.

• Weight Gain: Some individuals may experience weight gain, especially at higher doses or with prolonged use. Discuss any concerns with your healthcare team, who can assist in managing weight through diet and exercise.

• Vision Problems: Blurred vision has been reported in some cases. Report any vision changes to your healthcare team promptly to determine appropriate action.

• Low Platelet Count: Though uncommon, pregabalin ER can reduce platelet count, increasing bleeding risks. Seek medical attention if you experience unexplained bleeding or symptoms like dizziness or fainting.

There are no specific contraindications listed for pregabalin ER (Lyrica CR). Always consult your healthcare provider for personalized advice and to address any questions related to your health and medication use.