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When taking this medication, you may experience mild side effects such as constipation or stomach upset. These are generally manageable, but if they persist or worsen, it's important to inform your healthcare provider. Serious side effects are uncommon, but you should seek medical attention if you encounter symptoms like nausea, vomiting, loss of appetite, unusual weight loss, mood changes, signs of kidney issues (such as changes in urine output), bone or muscle pain, headaches, increased thirst or urination, weakness, tiredness, or a fast or pounding heartbeat.

Though a severe allergic reaction is rare, it requires immediate medical attention. Watch for symptoms such as rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. This list does not include all possible side effects. If you experience any other unusual symptoms, contact your healthcare provider for guidance.

Some drugs and products can interact with this medication. These include Digoxin and phosphate binders. Calcium can reduce the absorption of certain medications, such as tetracycline antibiotics (like doxycycline, Minocycline), bisphosphonates (such as Alendronate), estramustine, Levothyroxine, and quinolone antibiotics (like Ciprofloxacin, Levofloxacin). Additionally, some drugs can lower the absorption of vitamin D, including bile acid sequestrants (such as Cholestyramine, Colestipol), Mineral Oil, and Orlistat. It’s important to separate the timing of your doses of these medications from your calcium/vitamin D doses. Consult your doctor or pharmacist to determine the appropriate time intervals and to create a dosing schedule that accommodates all your medications.

Be sure to check the labels on all your prescription, over-the-counter, and herbal products (such as antacids, laxatives, and vitamins), as they might contain calcium, phosphate, or vitamin D. Your pharmacist can help ensure you use these products safely.

Since vitamin D is very similar to Calcitriol, avoid taking medications containing calcitriol while using vitamin D. This product may also interfere with certain lab tests, such as cholesterol tests, potentially leading to inaccurate results. Inform laboratory personnel and all your healthcare providers that you are using this product.