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The following is essential safety information regarding the use of doxazosin (Cardura), highlighting potential risks and necessary precautions. Please review these details and consult with your healthcare provider if you have any questions or concerns.

• Orthostatic Hypotension: When starting doxazosin (Cardura) or when your dose is increased, you may experience a sudden drop in blood pressure upon standing, known as orthostatic hypotension. Symptoms include dizziness, lightheadedness, blurry vision, fainting, nausea, or confusion. These effects may diminish as your body adjusts to the medication. Exercise caution when changing positions from sitting or lying to standing. If symptoms persist or if you experience a fall with a head injury, seek medical attention immediately. Risk factors include rapid position changes, dehydration, concurrent use of other blood pressure medications, heart failure, alcohol consumption, and advanced age.

• Prolonged and Painful Erection: Although uncommon, doxazosin (Cardura) may cause prolonged and painful erections, a condition that can require surgical intervention. If an erection lasts longer than four hours, discontinue use of the medication and seek emergency medical care.

• Eye Concerns: Doxazosin (Cardura) may lead to intraoperative floppy iris syndrome (IFIS) during cataract surgery, even if the medication is discontinued prior to the procedure. This condition can increase the risk of complications during and after surgery. Inform your eye surgeon if you are taking doxazosin (Cardura) to potentially adjust your surgical plan.

• Digestive Issues – Specific to Cardura XL: Rarely, Cardura XL (doxazosin) extended-release tablets have been associated with intestinal blockages. Report any instances of bloating, severe abdominal pain, nausea, or vomiting to your healthcare provider, especially if you have a history of gastrointestinal problems.

Please note that there are no specific contraindications listed for doxazosin (Cardura). Always communicate openly with your healthcare provider regarding your medical history and current medications to ensure safe use of this medication.

When taking this medication, you may experience some common side effects such as dizziness and lightheadedness, which can occur in 16-19% of users, as well as fatigue in 8-12% of users. These effects are generally mild, but if they persist or worsen, reaching out to a healthcare professional is recommended. To help reduce dizziness and lightheadedness, try getting up slowly from a sitting or lying position.

Other side effects that have been reported include headaches, respiratory tract infections, feeling weak, and drowsiness. Although these are less common, it is important to monitor them and consult with a healthcare provider if they become bothersome or severe.

Serious side effects, though rare, require immediate medical attention. These include signs of infection like a persistent sore throat or fever, fainting, shortness of breath, chest pain, swelling of the hands or feet, and low blood pressure. Men may rarely experience a painful or prolonged erection lasting four or more hours, which requires urgent medical care to prevent long-term issues.

In very rare cases, a serious allergic reaction might occur. Symptoms such as a rash, severe dizziness, swelling of the face, tongue, or throat, and trouble breathing necessitate immediate medical intervention. This summary does not cover all possible side effects, so if you notice any other unusual symptoms, contact your healthcare provider for advice.

When taking Doxazosin (Cardura), it's important to be aware of potential interactions with other medications. Inform your doctor and pharmacist about all the medicines, supplements, and over-the-counter products you are using. This includes alpha blockers like Prazosin and Tamsulosin, as well as erectile dysfunction medications such as Sildenafil and Tadalafil, which can lower blood pressure too much, leading to dizziness or fainting. Your doctor might adjust your treatment to reduce this risk.

Certain drugs can influence how Doxazosin is processed in your body, potentially altering its effectiveness. These include azole antifungals (e.g., Itraconazole, Ketoconazole), macrolide antibiotics (e.g., Clarithromycin), and HIV protease inhibitors (e.g., lopinavir, Ritonavir).

Additionally, some products, particularly those for coughs, colds, or weight loss and NSAIDs like Ibuprofen or Naproxen, might increase your blood pressure. Discuss all your current products with your pharmacist to ensure safe usage.