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Celecoxib, a nonsteroidal anti-inflammatory drug, carries potential risks and requires careful consideration before use. Below is a summary of important safety information and precautions:

• Heart Risks: Celecoxib may increase the likelihood of heart attack or stroke, particularly with long-term use, in older adults, or in those with pre-existing heart conditions. Avoid this drug around the time of heart bypass surgery. Contact emergency services if you experience chest pain, difficulty breathing, or sudden weakness on one side of the body.

• Stomach and Intestinal Bleeding: This medication can cause severe bleeding in the stomach or intestines, potentially life-threatening, sometimes without warning. Older adults and those on certain other medications are at higher risk. Seek immediate medical assistance if you experience persistent stomach pain, black/tarry stools, or vomit resembling coffee grounds.

• Liver Issues: Though rare, liver problems can occur, potentially leading to liver failure. Symptoms include fatigue, nausea, right-side abdominal pain, jaundice, and dark urine. Use the lowest effective dose for the shortest period to minimize risk.

• Blood Pressure and Heart Failure: Celecoxib might elevate blood pressure or cause fluid retention, increasing the risk of heart failure. Inform your healthcare provider if you have heart problems or are on blood pressure medications.

• Kidney Damage: The drug may impair kidney function, especially when combined with certain blood pressure medications or in the presence of pre-existing kidney conditions. Notify your provider of any changes in urination frequency.

• Allergic Reactions: Severe allergic reactions, such as anaphylaxis, can occur, particularly in individuals with sulfa allergies. Immediate medical attention is essential if symptoms like hives, swelling, or breathing difficulties arise.

• Asthma Warnings: Celecoxib may trigger severe asthma attacks, especially in those with a history of asthma or reactions to aspirin or other NSAIDs. Emergency care is crucial if breathing becomes difficult.

• Pregnancy Warnings: Using celecoxib after 20 weeks of pregnancy can harm an unborn baby, potentially causing heart or kidney issues. Discuss risks and alternatives with your healthcare provider if you are pregnant.

Contraindications:

• Allergies to celecoxib, other NSAIDs, or sulfa drugs.
• Recent coronary artery bypass surgery.

This information highlights the importance of discussing your medical history and current medications with your healthcare provider before starting celecoxib. Always seek medical advice for any concerns or adverse reactions.

When taking this medication, you might experience some common side effects which are usually mild and include headache, indigestion, upper respiratory infections, diarrhea, sinus infection, and belly pain. These effects are generally not serious but should be discussed with your healthcare provider if they persist or worsen.

Other less frequent side effects that have been observed include fever, cough, nausea, and symptoms of a common cold, such as a stuffy nose or sneezing. While these are more uncommon, monitoring their persistence and severity is important.

There are rare but serious side effects associated with this medication that demand immediate medical attention. These include swelling in the arms and legs, muscle or joint pain, back pain, vomiting, and severe allergic reactions characterized by rash, itching, swelling, severe dizziness, or trouble breathing. Additionally, symptoms such as pain or swelling in the groin or calf, changes in urine output, difficult swallowing, and signs of heart failure should be urgently addressed.

Another serious concern is liver damage, signaled by persistent nausea or vomiting, loss of appetite, dark urine, severe abdominal pain, or yellowing of the eyes or skin. If these symptoms occur, seek prompt medical help. It is also important to regularly monitor your blood pressure, as this medication can cause increases. Always keep your healthcare provider informed about any side effects you experience.

When taking Celebrex (celecoxib), it's crucial to be aware of potential interactions with other medications. Some drugs that should not be used with Celebrex include Ketorolac.

Additionally, combining Celebrex with certain medications might not be advisable, though your doctor could determine that using both is necessary. In such cases, your doctor may adjust the dosage or frequency of one or both medications. These include blood thinners like Warfarin, Dabigatran, and Enoxaparin; antiplatelet drugs such as Clopidogrel; and a range of anti-inflammatory drugs, diuretics, and various other medications.

Taking Celebrex with these drugs may heighten the risk of bleeding or other side effects. If you are prescribed low-dose Aspirin to prevent heart issues, continue taking it as directed by your doctor. Always inform your healthcare provider about all the medications and supplements you are currently using to manage these interactions effectively.