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Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), has important safety information that should be considered before use. Understanding the potential risks and taking necessary precautions can help ensure safe use of this medication.

• Increased Risk of Heart Attack and Stroke: Use of ketoprofen may elevate the risk of heart attack or stroke, particularly with long-term use. This risk is heightened in individuals with heart disease, those who have risk factors for heart disease (such as smoking or high blood pressure), and older adults. Avoid using ketoprofen immediately before or after coronary artery bypass graft (CABG) surgery.

• Risk of Stomach and Intestinal Bleeding: Ketoprofen can cause serious stomach or intestinal bleeding, which may occur without warning and be life-threatening. Those most at risk include older adults, individuals with a history of peptic ulcer disease or stomach bleeding, and those taking other NSAIDs or medications that increase bleeding risk. Alcohol and smoking can also increase the risk.

• Potential for High Blood Pressure and Heart Failure: This medication may cause fluid retention, potentially leading to high blood pressure and swelling. Excess fluid buildup can increase the risk of heart failure, especially in individuals with existing heart conditions.

• Kidney and Liver Concerns: Long-term use of ketoprofen can affect kidney function, particularly in patients with pre-existing kidney or liver problems or heart failure. It can also elevate liver enzyme levels, indicating possible liver damage.

• General Bleeding Risk: Ketoprofen increases the risk of bleeding, especially when combined with blood thinners or certain antidepressants. Notify a healthcare provider if you experience unusual bleeding or bruising.

• Severe Allergic Reactions: Some individuals may experience severe allergic reactions to ketoprofen, including anaphylaxis. Seek emergency help if you experience symptoms such as facial swelling, hives, or difficulty breathing. Avoid ketoprofen if you have known allergies to aspirin or other NSAIDs.

• Pregnancy Considerations: Ketoprofen can harm an unborn baby, particularly after the 20th week of pregnancy, increasing the risk of heart or kidney problems in the fetus. If you are pregnant or planning to become pregnant, discuss the risks and benefits with your healthcare provider.

• Contraindications: Do not use ketoprofen if you have a history of asthma or allergic reactions to aspirin or other NSAIDs, or if you are scheduled for or have recently undergone CABG surgery.

If you experience severe side effects such as persistent stomach pain, black or tarry stools, or vomit that resembles coffee grounds, seek immediate medical attention. Always discuss the potential benefits and risks of ketoprofen with your doctor or pharmacist before starting treatment.

Common side effects:

• upset stomach
• nausea
• constipation
• diarrhea
• gas
• headache
• dizziness
• drowsiness
• blurred vision

Less common but important to monitor:

• changes in hearing (like ringing in the ears)
• mood alterations
• easy bleeding or bruising
• difficulty swallowing
• changes in urine output
• blood in the urine
• swelling in the ankles or feet
• unusual tiredness
• sudden weight gain

Serious side effects:

• severe liver disease
• persistent nausea or vomiting
• loss of appetite
• stomach pain
• yellowing skin or eyes
• dark urine
• serious allergic reactions
• fever
• swollen lymph nodes
• rash
• severe dizziness
• breathing difficulties
• stomach bleeding
• heart attack
• stroke
• heart failure
• significant kidney issues
• fainting
• vomiting blood
• chest pain
• slurred speech
• severe headaches

Interactions with high risk of serious adverse effects and should be avoided:

• Ketorolac.

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Abciximab.
• Aspirin.
• Clopidogrel.
• Enoxaparin.
• Warfarin.
• ACE inhibitors (e.g., benazepril, lisinopril).
• Angiotensin II receptor blockers (e.g., losartan, valsartan).