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The following safety information highlights important considerations and warnings related to the use of ceftriaxone. Please review these points carefully and consult your healthcare provider if you have any questions or concerns.

• Allergic Reactions: There is a potential for allergic reactions to ceftriaxone, which can be severe, such as facial swelling, anaphylaxis, or shock. If you have a known allergy to antibiotics, especially penicillins or cephalosporins, inform your healthcare provider. Seek immediate medical attention if you experience symptoms like hives, rash, difficulty breathing, or swelling of the lips or tongue.

• Calcium Interaction: Avoid administering ceftriaxone through the same IV line as calcium-containing medications, such as calcium gluconate, calcium chloride injections, or total parenteral nutrition (TPN) with calcium. Mixing these can cause precipitates that may lead to gallbladder or kidney issues. If using the same line is unavoidable, ensure the line is properly flushed before administering ceftriaxone.

• Nervous System Effects: Though rare, ceftriaxone may cause serious nervous system side effects, including hallucinations, seizures, involuntary movements, or confusion. Individuals with kidney problems are at higher risk, particularly if their dose is not adjusted appropriately. Seek immediate help if these symptoms occur, as they generally resolve upon discontinuing the medication.

• C. difficile Infection: Ceftriaxone increases the risk of Clostridioides difficile infection, leading to potentially severe diarrhea. Symptoms include rapid heart rate, fever, foul-smelling diarrhea, nausea, or bloody stools. This is a medical emergency requiring prompt attention and testing.

• Hemolytic Anemia: Some patients may develop hemolytic anemia, resulting in a low red blood cell count. Contact your healthcare provider if you experience pale skin, fatigue, a fast heart rate, or difficulty breathing.

• Drug-Resistant Bacteria: To prevent the development of drug-resistant bacteria, it is crucial to take ceftriaxone as prescribed for the correct duration and condition. Misuse can lead to severe, treatment-resistant infections.

Contraindications

Ceftriaxone is not suitable for everyone. It should not be used in individuals with:

• Severe allergies to ceftriaxone, cephalosporins, penicillins, or other beta-lactam antibiotics.
• Premature newborns.

If any of these conditions apply to you, consult with your healthcare provider before using this medication.

Common side effects:

• swelling at the injection site
• redness at the injection site
• pain at the injection site
• rash
• itching
• nausea
• headache
• fever

Serious side effects:

• easy bruising or bleeding
• unusual tiredness
• symptoms of gallbladder disease
• symptoms of kidney problems
• severe intestinal condition linked to C. difficile
• serious allergic reactions
• methemoglobinemia
• oral thrush
• yeast infections

Interactions with high risk of serious adverse effects and should be avoided:

• Calcium Acetate
• Calcium Chloride
• Calcium Gluceptate
• Calcium Gluconate
• Lactated Ringer's Solution
• Ringer's Solution
• calcium-containing IV fluids

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Cholera Vaccine, Live

Interactions with low risk that usually do not require a change in therapy:

• Warfarin