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This safety information outlines important precautions and potential risks associated with the use of this medication. Please read carefully and speak with your healthcare provider if you have any questions or concerns.

• Severe Allergic Reactions: Some individuals may experience severe allergic reactions to cefprozil, including life-threatening conditions such as anaphylaxis, characterized by swelling of the face, lips, or tongue, shock, and difficulty breathing. If you have a known allergy to penicillin or other cephalosporin antibiotics, you may not be able to use this medication. Should you experience symptoms such as hives, red skin, or breathing difficulties after taking cefprozil, seek immediate medical attention.

• Diarrhea Due to Gut Infection: Using cefprozil can increase the risk of diarrhea caused by the bacterial infection Clostridioides difficile (C. diff), which can be severe. This bacteria is normally present in the gut without causing harm, but antibiotics can disrupt the balance of gut bacteria, allowing C. diff to proliferate.

• Drug-Resistant Bacteria Development: It is crucial to take cefprozil exactly as prescribed by your healthcare provider. Discontinuing the medication too soon or using it for conditions not prescribed can contribute to the development of drug-resistant bacteria, which can lead to severe infections that are difficult to treat.

• Phenylketonuria (PKU) Considerations: Individuals with phenylketonuria (PKU) should be aware that the cefprozil suspension contains phenylalanine. This can lead to serious health issues for those with PKU. Consult with your healthcare provider for safer alternative treatments.

Contraindications: This medication should not be used by individuals with a severe allergy to cephalosporin antibiotics, as doing so may result in serious health risks. Always consult your healthcare provider if you have any of these conditions before taking cefprozil.

Common side effects:

• Nausea
• Diarrhea
• Vomiting
• Stomach pain
• Dizziness
• Diaper rash

Less common but important to monitor:

• Persistent nausea or vomiting
• Unusual tiredness
• Yellowing of the skin or eyes
• Severe stomach pain
• Dark urine
• Signs of a new infection (sore throat, fever)
• Easy bruising
• Mental changes (confusion)
• Reduction in the amount of urine
• Oral thrush
• Vaginal yeast infection

Serious side effects:

• Severe intestinal condition linked to C. difficile
• Persistent diarrhea
• Abdominal cramping
• Blood or mucus in the stool
• Serious allergic reactions (rash, itching or swelling, severe dizziness, breathing difficulties)

Interactions with high risk of serious adverse effects and should be avoided:

• Cholera Vaccine, Live
• Desogestrel
• Dienogest
• Drospirenone
• Estradiol
• Ethinyl Estradiol
• Ethynodiol
• Gestodene
• Levonorgestrel
• Mestranol
• Nomegestrol
• Norethindrone
• Norgestimate
• Norgestrel

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Probenecid