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This document outlines important safety information and warnings regarding the use of lactulose (Constulose). It is crucial to understand the potential risks and necessary precautions. Please discuss any questions or concerns with your healthcare provider.

• Dehydration Risk: Lactulose (Constulose) may cause dehydration, which can disrupt the balance of essential minerals such as sodium, potassium, and calcium in your body. Regular monitoring of these electrolytes by your healthcare professional is advised, especially for individuals over 65 years of age or those on long-term lactulose therapy. Contact your healthcare provider immediately if you experience extreme thirst, fatigue, or confusion, as these may indicate dehydration and electrolyte imbalance.

• Blood Sugar Considerations: Lactulose (Constulose) contains sugars, including galactose and lactose. While research suggests it may not significantly increase blood sugar levels, individuals with diabetes should regularly monitor their blood sugar levels during treatment.

• Colonoscopy Preparations: Inform your healthcare team if you are taking lactulose (Constulose) if you are scheduled for a colonoscopy or rectal exam. Alternative medications may be recommended to prepare your gut for the procedure.

Contraindications:

• Lactulose (Constulose) should not be used by individuals on a low-galactose diet due to potential health risks. Consult your healthcare provider if this applies to you.

Ensure you follow these guidelines carefully and maintain open communication with your healthcare provider to safely manage your treatment.

When taking this medication, some common side effects you might experience include gas, bloating, burping, stomach rumbling, mild stomach pain, nausea, and cramps. These effects are generally mild and tend to resolve on their own. However, if they persist or become bothersome, it's advisable to consult with a healthcare professional for guidance.

In some cases, more significant side effects may occur, such as severe stomach or abdominal pain, persistent diarrhea, vomiting, muscle cramps or weakness, irregular heartbeat, mental or mood changes, seizures, bloody stools, or rectal bleeding. These symptoms are more serious and require immediate medical attention to ensure your safety and well-being.

Although a very serious allergic reaction to this medication is rare, it's important to seek urgent medical help if you notice symptoms such as a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. These could indicate a severe allergic reaction needing prompt care. If you notice any other effects not mentioned here, reaching out to a healthcare provider is recommended to address any concerns you may have.

Lactulose (Constulose) can interact with a variety of medications and supplements. It's important to inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescription, over-the-counter, vitamins, or herbal products. This helps them manage potential interactions effectively.

Some products that might interact with Lactulose include antacids containing aluminum or magnesium, and other laxatives. These interactions could potentially impact how Lactulose works.

There are also specific medications that should not be used with Lactulose. Your doctor may choose to avoid these combinations or adjust your treatment plan. These medicines include Amantadine, Atropine, Belladonna, and several others such as Benztropine, Bepridil, and Biperiden, among others.

Additionally, there are medications that are usually not recommended with Lactulose, but might be necessary in certain situations. If these are prescribed together, your healthcare provider may adjust the dosages or frequency of these medications. This list includes drugs like Acalabrutinib, Alacepril, Alfuzosin, Amiloride, and many others.

Always consult with your healthcare provider to ensure safe and effective use of Lactulose with any other medications or supplements you may be taking.