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This safety information outlines important warnings and contraindications for the use of Xifaxan (rifaximin). Please review the details below and discuss any concerns with your healthcare provider.

• Potential Worsening of Travelers' Diarrhea: Xifaxan is effective for treating travelers' diarrhea caused by the E. coli bacteria. However, it may not be effective against other organisms that can cause similar symptoms. Using Xifaxan in such cases might lead to a worsening condition if the appropriate treatment is not administered.

• Risk of Clostridioides difficile Infection: The use of antibiotics, including Xifaxan, can disrupt the normal balance of bacteria in the stomach and intestines. This disruption can result in the overgrowth of Clostridioides difficile (C. diff), a bacteria that can cause severe and potentially life-threatening diarrhea. It is crucial to monitor for symptoms and seek medical advice if necessary.

Contraindications:

• Severe Allergies: Do not use Xifaxan if you have a known severe allergy to it or related antibiotics such as rifampin or rifabutin. Consult your healthcare provider for alternative treatment options if this applies to you.

For any concerns or further clarification, please contact your healthcare professional.

While taking this medication, some people may experience common side effects such as headaches, which occur in about 10% of users. These are generally mild and should not cause concern unless they persist or worsen, in which case consulting a healthcare provider is advisable.

Other side effects reported include nausea, affecting 2-3% of users. While this is typically not serious, if you experience persistent or severe nausea, it is important to contact your healthcare provider for advice.

Rarely, the medication may lead to severe side effects like a significant intestinal condition caused by C. difficile bacteria. Symptoms to watch for include persistent diarrhea, abdominal pain, and blood or mucus in the stool. It's crucial to seek medical attention immediately if these occur and avoid using anti-diarrhea or opioid products, as they might exacerbate the condition.

A very serious allergic reaction to this medication is also rare but requires immediate medical help. Be alert for symptoms such as rash, itching or swelling of the face, tongue, or throat, severe dizziness, and trouble breathing.

Some users have also reported more severe side effects that demand urgent medical attention, such as swelling in the hands and feet, dizziness, tiredness, and extra stomach fluid and swelling. If you notice any of these symptoms, seek medical care promptly. Always report any side effects you experience to your healthcare provider.