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This medication comes with significant safety warnings and precautions that are important to understand. Please review the following information thoroughly and consult your healthcare provider if you have any questions or concerns.

• Kidney Damage and Kidney Stones: Mesalamine (Canasa) has the potential to harm your kidneys. The risk is heightened if you have pre-existing kidney issues or are taking other kidney-affecting medications such as NSAIDs or diuretics. Regular blood and urine tests may be necessary to monitor kidney function. Contact your healthcare provider immediately if you experience symptoms like changes in urination, fatigue, loss of appetite, or muscle cramps.

• Acute Intolerance Syndrome: Although rare, some individuals may experience acute intolerance syndrome when using mesalamine (Canasa), typically within one to three weeks of starting the medication. Symptoms usually resolve a few days after discontinuing use or commencing corticosteroid treatment.

• Severe Allergic Reactions: There is a risk of severe allergic reactions, including potentially life-threatening conditions such as facial swelling, shock, or anaphylaxis. Seek emergency medical assistance by calling 911 if you experience hives, rashes, swelling of the lips or tongue, or difficulty breathing.

• Severe Skin Reactions: Rare but serious skin reactions can occur, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and DRESS syndrome. Discontinue use and seek medical attention immediately if you notice rash, blisters, peeling skin, or skin redness. These symptoms may occur alongside fever, sore throat, fatigue, and swollen lymph nodes.

• Liver Problems: In individuals with liver disease, mesalamine can cause liver failure. Inform your healthcare provider of any liver conditions before starting treatment. Seek immediate medical help if you experience severe nausea, vomiting, right-sided abdominal pain, fatigue, appetite loss, or jaundice, as these may indicate liver damage.

• Sun Sensitivity: Those with skin conditions such as eczema are more susceptible to sunburn when taking mesalamine (Canasa), even during winter or cloudy days. Take extra precautions to protect your skin from UV exposure.

• Contraindications: Do not use this medication if you have a known allergy to aspirin or other salicylates, as it may lead to serious health complications. Always consult with your healthcare provider before starting mesalamine (Canasa) if you have concerns related to these contraindications.

Common side effects:

• Dizziness
• Rectal pain

Less common but important to monitor:

• Fever
• Rash
• Acne
• Inflammation of the colon

Serious side effects:

• Kidney damage symptoms (reduced urination, dry and itchy skin, muscle cramps, swelling in the extremities)
• Kidney stones symptoms (difficulty urinating, bloody urine, fever, chills, back or side pain)
• Liver problems (stomach bloating, right-sided stomach pain, yellowing of the skin or eyes, dark urine)
• Serious allergic reactions (hives, swelling of the lips or tongue, difficulty breathing)
• Serious skin reactions (hives, blisters, peeling or reddened skin, fever, sore throat, swollen lymph nodes)

When taking mesalamine, it's important to be aware of potential interactions with other medications:

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Combining mesalamine with NSAIDs like Ibuprofen or Naproxen may increase the risk of kidney problems. Patients should be monitored for changes in kidney function when using these medications together.

• Azathioprine and 6-Mercaptopurine: Using mesalamine alongside these immunosuppressants can heighten the risk of blood disorders and bone marrow suppression. Regular blood tests are recommended to monitor for these potential complications.

• Antacids: Certain mesalamine formulations, such as Apriso, have a pH-dependent release mechanism. Taking antacids concurrently can interfere with the medication's effectiveness. It's advisable to avoid using antacids with these specific mesalamine products.

• Tricyclic Antidepressants (TCAs): There is evidence suggesting that mesalamine may interact with TCAs through the CYP2D6 enzyme pathway, potentially leading to adverse effects. Patients should consult their healthcare provider before combining these medications.

• Warfarin: Mesalamine may alter the effects of warfarin, an anticoagulant, increasing the risk of bleeding. Close monitoring of blood clotting parameters is essential when these drugs are used together.

• Salsalate: Combining mesalamine with salsalate, another anti-inflammatory drug, may elevate the risk of gastrointestinal bleeding. It's generally recommended to avoid using these medications concurrently.

Always inform your healthcare provider about all medications and supplements you are taking to ensure safe and effective treatment.