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The safety information below highlights essential warnings associated with the use of Solu-Cortef (hydrocortisone). It is crucial to understand these risks and consult with your healthcare provider if you have any concerns.

• Skin Changes: Use of Solu-Cortef (hydrocortisone) may lead to fat loss and skin alterations at the injection site, particularly with higher doses. Avoid injections into the deltoid muscle to reduce this risk.

• Heart and Kidney Concerns: This medication can cause increased blood pressure, weight gain, and impact kidney function, particularly in individuals with a history of heart failure, hypertension, or kidney issues. Regular monitoring of vitals and lab tests is recommended.

• Adrenal Suppression: Long-term use can suppress adrenal gland function, leading to symptoms such as joint pain, fatigue, and dizziness. Report any side effects to your healthcare provider promptly.

• Increased Infection Risk: Prolonged use can weaken the immune system, elevating infection risk and masking infection signs. Avoid contact with individuals with chickenpox or measles, and consult your prescriber before receiving any vaccines.

• Stomach Issues: There is an increased risk of stomach damage, particularly in those with a history of ulcers or who take medications like ibuprofen. Immediate medical attention is advised if you experience persistent stomach pain or notice blood in stools.

• Bone Health: Long-term use may weaken bones and slow growth in children, increasing fracture risk. Pediatric growth should be monitored closely during treatment.

• Mood and Behavioral Changes: Solu-Cortef may affect mood and behavior, causing depression, anxiety, or hallucinations. Any such changes should be reported to your healthcare provider.

• Eye Complications: Prolonged use increases the risk of cataracts, glaucoma, and certain infections. Regular eye exams may be necessary, and use is contraindicated if you have an eye herpes simplex infection.

Contraindications: Do not use Solu-Cortef if you have a widespread fungal infection, a blood condition with low platelet levels (for IM use), or plan to administer it intrathecally. Always discuss with your healthcare provider before starting this medication.

When using this medication, some individuals may encounter common side effects such as stomach upset, headache, dizziness, or trouble sleeping. Changes in appetite, menstrual cycle alterations, acne, and minor discomfort at the injection site might also occur. These effects are usually mild, but if they persist or worsen, consult your healthcare provider for advice. It's important to monitor your blood pressure and blood sugar levels, as this medication may cause increases in both, potentially affecting individuals with or without pre-existing conditions like diabetes.

More serious side effects, though rare, should be taken seriously. If you notice symptoms such as unusual weakness, puffy face, or muscle pain, it’s important to reach out to your healthcare provider. Pay attention to unusual weight gain, slow wound healing, and changes in mood or vision, as these could indicate more significant issues. Additionally, watch for signs of infection, such as a persistent sore throat or fever, which could signal a lowered ability to fight infections. In very rare cases, severe allergic reactions may occur, characterized by rash, itching, or difficulty breathing, and require immediate medical attention.

Lastly, severe symptoms like stomach or intestinal bleeding, seizures, or changes in electrolyte levels are critical and demand urgent medical care. Always remain aware of how your body responds to the medication and maintain open communication with your healthcare provider regarding any concerns.