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The safety and warning information below is crucial for anyone using budesonide (Uceris) rectal foam. Please read these points carefully and consult your healthcare provider if you have any concerns or questions.

• Altered Cortisol Levels: Using corticosteroids like budesonide can reduce your body's production of natural stress hormones. This is more likely with higher doses or prolonged use. Abruptly stopping the medication may lead to symptoms such as weakness, nausea, and diarrhea due to low cortisol levels. These effects are generally temporary, and your hormone levels should stabilize over time. Inform your gastroenterologist if you experience any symptoms of low cortisol. Risk: Prolonged use of budesonide rectal foam.

• Steroid Withdrawal Symptoms: Transitioning from another steroid, particularly oral forms, to budesonide rectal foam can cause withdrawal symptoms and increased intracranial pressure. Do not switch steroids without consulting your healthcare provider, who may gradually taper your current steroid dosage while monitoring your cortisol levels. Risk: Transitioning from oral corticosteroids to budesonide rectal foam.

• Increased Infection Risk: Budesonide can suppress your immune system, increasing the risk of infections or worsening existing ones. If you have or are exposed to infections like chickenpox or tuberculosis, contact your healthcare provider immediately for treatment. Avoid contact with individuals who have these illnesses. If you experience symptoms such as fever, chills, nausea, or fatigue, notify your provider. Risk: Compromised immune system, History of frequent infections, Existing infections, Concurrent use of immunosuppressive drugs.

• Exacerbation of Certain Conditions: Budesonide may aggravate certain health conditions, including raising blood pressure and glucose levels, causing bone loss, stomach ulcers, and eye issues like glaucoma or cataracts. If you have a history of such conditions, inform your gastroenterologist prior to starting treatment. Dosage adjustments may be necessary. Risk: High blood pressure, Diabetes, Osteoporosis, Stomach ulcers, Glaucoma, or cataracts.

No contraindications have been identified for budesonide (Uceris) rectal foam.

When taking this medication, you might experience some common side effects, although they are generally mild. These include nausea, abdominal pain, headache, low blood cortisol levels, and trouble sleeping (insomnia). If these effects persist or worsen, it is important to consult your healthcare provider for advice and reassurance.

Occasionally, individuals may notice other side effects such as acne, swelling in the arms, legs, hands, or feet, fever, dizziness, mood changes, itching, or a rash. While these are not uncommon, it is advisable to contact your healthcare provider if they occur, especially if they become bothersome.

This medication may also cause more serious side effects due to its immune system effects, potentially increasing the likelihood of infections. Seek immediate medical attention if you experience symptoms such as a persistent sore throat, fever, chills, or cough. Additionally, watch for signs of oral thrush or a new yeast infection, which could manifest as white patches in the mouth or changes in vaginal discharge.

It is crucial to be vigilant for serious side effects like easy bruising or bleeding, unusual weight gain, menstrual changes, muscle or bone pain, thinning skin, slow wound healing, increased thirst or urination, vision problems, or signs of stomach bleeding such as abdominal pain or vomit resembling coffee grounds. A rare but serious allergic reaction could include symptoms like rash, swelling, severe dizziness, and trouble breathing, which require urgent medical help.

While this list covers the most notable side effects, it is not exhaustive. If you notice any additional issues, reaching out to your healthcare provider is recommended to ensure your safety and well-being.

When using Budesonide (Uceris) rectal foam, be aware that it can interact with a variety of other drugs. Notably, it is advisable to avoid combining this medication with desmopressin. Additionally, caution is necessary when using it alongside certain other medications, as they may generally not be recommended together unless specifically advised by your healthcare provider. These include numerous anti-inflammatory drugs like Celecoxib, Ibuprofen, and Diclofenac, among others. If these drugs are used together, your doctor might adjust the dosage or frequency of one or both medications to minimize potential risks.

Moreover, some medications, such as Auranofin, Erythromycin, and Ketoconazole, may increase the likelihood of side effects when used with Budesonide. However, your doctor might still recommend them if they are deemed beneficial for your treatment plan, possibly with adjusted dosages.

It is crucial to inform your doctor and pharmacist about all medications and supplements you are currently taking, including over-the-counter drugs, vitamins, and herbal products, to prevent any possible interactions. Additionally, Budesonide may interfere with certain laboratory tests, leading to inaccurate results, so ensure all healthcare personnel are aware of your use of this drug. If you're taking low-dose aspirin to prevent heart issues, continue only under your doctor's guidance.