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The safety information below outlines essential warnings regarding the use of Tolterodine (Detrol). Please read carefully and discuss any concerns with your healthcare provider.

• Angioedema Risk: Tolterodine (Detrol) may cause swelling of the face, lips, tongue, or throat, known as angioedema. This reaction can occur immediately after the first dose or after prolonged use. If you experience facial swelling, difficulty breathing, airway blockage, or sudden dizziness, discontinue the medication and seek emergency medical attention.

• Dizziness and Drowsiness: This medication may induce dizziness, drowsiness, or decreased alertness, especially when you begin treatment or increase the dosage. Avoid driving or engaging in activities requiring focus until you understand how Tolterodine affects you. Be cautious when consuming alcohol or taking other medications that can impair alertness.

• Vision Changes: Temporary vision changes, such as blurred vision, may occur with Tolterodine. There is a rare risk of developing narrow-angle glaucoma. This medication is contraindicated if you have uncontrolled narrow-angle glaucoma. Consult your eye doctor if you are uncertain about your glaucoma type.

• Urinary and Gastrointestinal Issues: Notify your healthcare provider if you experience urinary retention due to bladder blockage, as Tolterodine can exacerbate this condition. It may also worsen pre-existing stomach or intestinal issues.

• Liver and Kidney Considerations: Individuals with liver or kidney problems should inform their healthcare provider, as these organs are crucial in processing and eliminating Tolterodine. Impaired function may increase side effects such as dry mouth and dizziness. A lower dose may be prescribed, but Tolterodine is not recommended for severe liver or kidney disease.

• Myasthenia Gravis Precaution: Patients with myasthenia gravis should consult their provider before using Tolterodine, as it may worsen muscle weakness symptoms.

• Heart Rhythm Concerns: If you have heart rhythm issues or are taking medications to manage your heartbeat, inform your healthcare provider. Tolterodine may cause potentially harmful changes in heart rhythm. Discuss the risks and benefits with your provider.

Contraindications: Tolterodine should not be used if you have the following conditions, as they pose significant health risks:

• Blockage in the bladder, stomach, or intestines
• Uncontrolled narrow-angle glaucoma
• Allergy to Toviaz (fesoterodine)

Always consult with your healthcare provider to ensure safe use of this medication in light of your personal health conditions and history.

When using this medication, you may experience some common side effects, which are often mild and manageable. These include dry mouth, headache, constipation, stomach pain, dizziness, dry eyes, drowsiness, and fatigue. If these symptoms persist or worsen, it's advisable to discuss them with your healthcare provider. To help alleviate dry mouth, consider using sugarless candy or gum, drinking water, or using a saliva substitute. For constipation relief, a diet rich in fiber, adequate hydration, and regular exercise can be beneficial.

In addition to these, some individuals might experience other side effects such as diarrhea, indigestion, or swollen sinuses. If you notice any of these symptoms, particularly if they are bothersome, consult your healthcare provider.

There are also rare but serious side effects that necessitate immediate medical attention. These include significant vision changes, severe abdominal pain, difficulty urinating, signs of a kidney infection, and flu-like symptoms. Moreover, allergic reactions, though uncommon, can occur and may manifest as rash, swelling, or trouble breathing. Should you experience fast, slow, or irregular heartbeat, severe dizziness, or fainting, seek urgent medical care without delay.

While this list covers many potential side effects, it's not exhaustive. If you experience any unusual symptoms not mentioned here, contacting your healthcare provider is recommended.

Tolterodine (Detrol) can interact with various medications and supplements, so it's essential to inform your doctor and pharmacist about all the medications, including over-the-counter drugs, vitamins, and supplements you are taking. Here are key interactions to be aware of:

1. Medications to Avoid with Tolterodine: It is generally advised not to use Tolterodine with certain drugs such as Bepridil, Cisapride, Dronedarone, Mesoridazine, Pimozide, Piperaquine, Potassium, Saquinavir, Sparfloxacin, Terfenadine, Thioridazine, and Ziprasidone. If you are taking any of these, your doctor might reconsider prescribing Tolterodine or adjust your other medications.

2. Cautionary Drug Combinations: While not typically recommended, some medications may be used with Tolterodine under careful medical supervision. These include Amiodarone, Amisulpride, Anagrelide, Apomorphine, Aripiprazole, Aripiprazole Lauroxil, Arsenic Trioxide, Buprenorphine, Bupropion, and several others. Your doctor may adjust dosages or monitor you more closely if these drugs are prescribed together.

3. Potential Side Effect Risk: Using Tolterodine with certain medications might increase the risk of side effects. Such drugs include Cyclosporine, Erythromycin, Galantamine, Itraconazole, Miconazole, Propafenone, Quinidine, Rivastigmine, Vinblastine, and Warfarin. Your doctor may change how often or how much you use one or both medications.

Additionally, Tolterodine can affect heart rhythm, known as QT prolongation. Medications like amiodarone, Dofetilide, pimozide, procainamide, quinidine, Sotalol, and some antibiotics such as erythromycin may also influence this. Discuss any use of these drugs with your healthcare provider.

Lastly, Tolterodine can increase drowsiness. Inform your healthcare provider if you consume alcohol, marijuana, or are using antihistamines, sleep or anxiety medications, muscle relaxants, or opioid pain relievers, as these can also cause drowsiness. Always check medicine labels for ingredients that may contribute to drowsiness, and consult your pharmacist for safe use.