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The following safety and warning information is crucial for patients and healthcare professionals considering the use of Tolterodine (Detrol). Please read carefully and consult your healthcare provider if you have any concerns or questions.

• Angioedema Risk: Tolterodine (Detrol) can cause swelling of the face, lips, tongue, or throat, known as angioedema. This may occur shortly after the first dose or after prolonged use. If you experience facial swelling, difficulty breathing, airway blockage, or sudden dizziness, discontinue use immediately and seek emergency medical assistance.

• Dizziness and Drowsiness: This medication can induce dizziness, drowsiness, or reduced alertness, especially at the beginning of treatment or after a dosage increase. Avoid driving or operating machinery until you know how Tolterodine affects you. These effects can be exacerbated by alcohol or other medications that reduce alertness.

• Vision Changes: Temporary vision changes, such as blurred vision, can occur. Furthermore, Tolterodine may increase the risk of narrow-angle glaucoma. It is contraindicated for those with uncontrolled narrow-angle glaucoma. Consult your ophthalmologist if you are unsure about your glaucoma status.

• Urinary and Gastrointestinal Issues: Notify your healthcare provider if you have urinary difficulties due to bladder blockage, as Tolterodine can exacerbate these issues. Those with a history of bladder, stomach, or intestinal problems should also exercise caution.

• Liver and Kidney Concerns: Patients with liver or kidney conditions should inform their healthcare provider. These organs play a crucial role in processing and eliminating Tolterodine, and impairment can lead to an accumulation of the drug, increasing the risk of side effects like dry mouth and dizziness. A reduced dose may be necessary, but the medication is not recommended for severe organ dysfunction.

• Myasthenia Gravis Consideration: Individuals with myasthenia gravis should consult their healthcare provider before using Tolterodine, as it may exacerbate muscle weakness associated with this condition.

• Heart Rhythm Considerations: If you have a history of heart rhythm issues or are taking medications to manage your heartbeat, discuss the risks and benefits of Tolterodine with your healthcare provider, as it may cause dangerous changes in heart rhythm.

Contraindications for the use of Tolterodine (Detrol) include:

• Blockages in the bladder, stomach, or intestines.
• Uncontrolled narrow-angle glaucoma.
• An allergy to Toviaz (fesoterodine).

Always consult your healthcare provider to ensure this medication is appropriate for your condition and circumstances.

Common side effects:

• Dry mouth
• Headaches
• Constipation
• Stomach pain
• Dizziness
• Drowsiness
• Fatigue
• Dry eyes
• Blurred vision

Less common but important to monitor:

• Diarrhea
• Indigestion
• Swollen sinuses
• Flu-like symptoms

Serious side effects:

• Significant changes in vision
• Severe abdominal pain
• Trouble urinating
• Symptoms of a kidney infection
• Allergic reaction
• Irregular heartbeat
• Severe dizziness
• Fainting

Interactions with high risk of serious adverse effects and should be avoided:

• Bepridil
• Cisapride
• Dronedarone
• Mesoridazine
• Pimozide
• Piperaquine
• Potassium
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amiodarone
• Amisulpride
• Aripiprazole
• Clarithromycin
• Sotalol
• Cyclosporine
• Erythromycin
• Warfarin

Interactions with low risk that usually do not require a change in therapy:

• Mifepristone
• Pramlintide
• Alcohol
• Marijuana (cannabis)
• Cetirizine
• Diphenhydramine
• Alprazolam
• Diazepam
• Zolpidem
• Codeine