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When using Tolterodine (Detrol), it is crucial to be aware of the potential risks and precautions associated with this medication. Below are important safety considerations and instructions you should follow. Always discuss any concerns with your healthcare provider.

• Swelling and Allergic Reactions: Tolterodine can lead to angioedema, which is swelling of the face, lips, tongue, or throat. This can occur immediately after the first dose or after prolonged use. If you notice facial swelling, breathing difficulties, airway obstruction, or sudden dizziness, discontinue use and seek emergency medical attention.

• Dizziness and Drowsiness: This medication may cause dizziness, drowsiness, or reduced alertness, especially when starting treatment or increasing the dose. Avoid driving or engaging in activities that require full attention until you know how Tolterodine affects you. Contributing factors include alcohol consumption and other medications that impair alertness.

• Vision Changes: Temporary vision changes, such as blurred vision, may occur. Tolterodine may increase the risk of narrow-angle glaucoma. It is not suitable for individuals with uncontrolled narrow-angle glaucoma. Consult your eye doctor if you are uncertain about your glaucoma status.

• Urination and Digestive Issues: Inform your healthcare provider if you experience difficulty urinating due to bladder obstruction, as Tolterodine can exacerbate this condition. Those with a history of bladder or digestive issues should also exercise caution.

• Liver and Kidney Considerations: Individuals with liver or kidney problems should alert their healthcare provider. These organs are essential for processing and eliminating Tolterodine, and impaired function can increase the risk of side effects. A lower dose may be recommended, but those with severe liver or kidney disease should avoid this medication.

• Myasthenia Gravis: If you have myasthenia gravis, consult your provider prior to using Tolterodine, as it may aggravate muscle weakness symptoms.

• Heart Rhythm Disorders: Those with heart rhythm issues or who are on medication to regulate heartbeat should inform their provider, as Tolterodine can alter heart rhythms, posing potential dangers. Your provider will evaluate the risks and benefits.

Contraindications:

• Do not use Tolterodine if you have a blockage in the bladder, stomach, or intestines, uncontrolled narrow-angle glaucoma, or an allergy to Toviaz (fesoterodine).

Always ensure to provide your complete medical history to your healthcare provider to prevent serious health risks.

When taking this medication, you might experience some common side effects that are generally mild and manageable. These include dry mouth, headache, constipation, stomach pain, dizziness, drowsiness, tiredness, dry eyes, and blurred vision. Such effects are typically temporary, but if they persist or worsen, consult your healthcare provider. To alleviate dry mouth, consider using sugarless hard candy or gum, drinking plenty of water, or trying a saliva substitute. For constipation, dietary fiber, adequate hydration, and regular exercise can be beneficial, and a pharmacist can advise on appropriate laxatives.

In addition to these, some individuals may experience diarrhea, indigestion, swollen sinuses, flu-like symptoms, or painful urination. Although these are less common, it's important to be aware of them and seek medical advice if they occur.

There are also serious side effects, which, though rare, require immediate medical attention. These include significant vision changes, severe stomach or abdominal pain, trouble urinating, or signs of a kidney infection such as burning or painful urination, lower back pain, or fever. Immediate help is also crucial if you experience fast, slow, or irregular heartbeat, severe dizziness, fainting, or symptoms of an allergic reaction like rash, itching, swelling (especially of the face, tongue, or throat), or trouble breathing. Always contact your healthcare provider if you notice any side effects not listed here.

When taking Tolterodine (Detrol), it’s important to be aware of potential interactions with other medications or supplements you may be using. This drug can interact with various substances, potentially affecting your heart rhythm or causing other side effects.

Some medications should not be taken with Tolterodine, as they could lead to serious interactions. These include Bepridil, Cisapride, Dronedarone, Mesoridazine, Pimozide, Piperaquine, certain Potassium supplements, Saquinavir, Sparfloxacin, Terfenadine, Thioridazine, and Ziprasidone. Your doctor may choose to either not prescribe Tolterodine or adjust your other medications.

There are other drugs that usually should not be combined with Tolterodine but might be necessary in some situations. In such cases, your doctor will carefully manage your doses. These include Amiodarone, Amisulpride, Anagrelide, and several others such as Apomorphine, Clarithromycin, Clozapine, and Hydroxychloroquine.

Additionally, using Tolterodine with certain drugs like Cyclosporine, Erythromycin, Itraconazole, and Warfarin may increase the risk of side effects. In these cases, your healthcare provider may adjust how often you take these drugs.

Moreover, be cautious with products that cause drowsiness. This includes alcohol, marijuana, antihistamines like Cetirizine and diphenhydramine, sleep or anxiety medications such as Alprazolam and Diazepam, muscle relaxants, and opioid pain relievers like codeine. Always check the labels of over-the-counter products, like those for allergies or colds, as they may contain ingredients that induce drowsiness. Consult with your pharmacist or healthcare provider to ensure safe usage of these products alongside Tolterodine.