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This safety information outlines important warnings and precautions for using Gelnique (oxybutynin). Carefully consider these points and discuss any concerns with your healthcare provider.

• Exacerbation of Pre-existing Conditions: Gelnique (oxybutynin) may worsen symptoms of certain medical conditions due to its mechanism and side effects, such as difficulty urinating or emptying the stomach. Exercise caution if you have urinary retention issues, gastrointestinal conditions like ulcerative colitis or acid reflux, or myasthenia gravis. Additionally, using bisphosphonates for bone loss alongside this medication can aggravate digestive tract problems. Ensure your healthcare provider is aware of your complete medical history before starting treatment.

• Angioedema Risk: Although more common with oral tablets, angioedema (swelling of the face, lips, tongue, or throat) can occur with Gelnique (oxybutynin) and may impair breathing. Seek medical attention if you experience persistent swelling in the head or neck.

• Skin Sensitivity: In clinical studies, some users developed skin hypersensitivity to Gelnique (oxybutynin). Discontinue use and contact your healthcare provider if you notice severe skin changes after application.

• Neurological Effects: This medication may cause confusion, drowsiness, and hallucinations, particularly at the start of treatment. Inform your healthcare provider if you experience these effects, as dosage adjustments or alternative treatments may be necessary.

• Transfer Through Contact: Gelnique (oxybutynin) can be transferred to others through direct skin contact. To prevent this, cover the treated area with clothing if expecting skin-to-skin contact with others.

• Flammability: As an alcohol-based gel, Gelnique (oxybutynin) is flammable. Avoid smoking or exposure to open flames until the gel has dried completely.

Contraindications: Do not use Gelnique (oxybutynin) if you have any of the following conditions, as it may pose significant health risks:

• Urinary retention (inability to empty the bladder fully).
• Gastric retention (inability to empty the stomach fully).
• Uncontrolled narrow-angle glaucoma.

Always consult your healthcare provider if you have any questions or concerns regarding the use of this medication.

When using this medication, you might encounter some side effects, though they are often mild and manageable. Common reactions include dry mouth, which affects about 8% of users, and skin reactions at the application site, such as itching, bumps, or redness, occurring in roughly 5% of cases. Dizziness is reported by 3% of individuals, and some may experience symptoms of a common cold or urinary tract infections. Additionally, upper respiratory tract infections, presenting with cough or sore throat, are noted in about 5% of users.

To alleviate dry mouth, consider sipping water, chewing sugarless gum, or using saliva substitutes. Skin reactions can be uncomfortable, but if they persist, consult with your healthcare provider. Dizziness and mild infections typically resolve on their own, but should symptoms worsen, seeking medical advice is recommended.

There are other side effects that some may experience, such as low energy, headaches, stomach flu, constipation, and general itching. While these are generally not severe, it’s important to monitor how you’re feeling and discuss any concerns with a healthcare professional.

In rare instances, serious side effects can occur. These include difficulty urinating, signs of kidney infection, or severe stomach and intestinal issues, such as persistent nausea, vomiting, or severe constipation. Mental or mood changes like confusion and hallucinations also warrant immediate medical attention. Although very serious allergic reactions are rare, seek emergency care if you experience symptoms such as rash, severe dizziness, or trouble breathing. Always communicate with your healthcare provider about any side effects you experience.

When taking Gelnique (oxybutynin), it is important to be aware of potential interactions with other medications or supplements. Inform your doctor and pharmacist about all the medications and supplements you are currently using, including prescription, over-the-counter, vitamins, and herbal products.

Certain medications should not be combined with Gelnique. For example, using potassium supplements can irritate the esophagus and stomach, and is not recommended. In some situations, using drugs such as bupropion, clozapine, donepezil, glucagon, glycopyrrolate, glycopyrronium tosylate, methacholine, quetiapine, revefenacin, scopolamine, secretin human, and tiotropium with Gelnique may require monitoring and dosage adjustments by your doctor.

There are also medicines like galantamine, ketoconazole, and rivastigmine which, when taken with Gelnique, may increase the risk of side effects. Despite this, they might be necessary for your treatment plan, and your doctor will adjust the dosage or frequency accordingly.

Additionally, be cautious with products that cause drowsiness, such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), and certain antihistamines (e.g., cetirizine, diphenhydramine). These can enhance drowsiness, constipation, or blurred vision. Always check medicine labels and consult your pharmacist for safe usage.