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The safety information for this medication is crucial for its proper use and to avoid potential risks. Please review the following points carefully and consult your healthcare provider with any questions or concerns.

• Intended Use: Vaniqa (eflornithine) is designed exclusively for external use on the skin, specifically targeting the face and areas beneath the chin.

• Application Caution: Avoid applying the medication to broken skin, as it may cause temporary stinging or burning at the site. If this sensation is persistent or uncomfortable, contact your healthcare provider.

• Eye Exposure: In the event of accidental contact with the eyes, rinse thoroughly with water immediately to prevent irritation or damage. Notify your prescriber promptly for further guidance.

It is crucial to adhere to these instructions to ensure safe and effective use of the medication.

Common side effects:

• Acne
• Razor bumps
• Stinging skin
• Headache
• Burning sensations
• Itching
• Tingling
• Dry skin
• Rashes
• Redness
• Skin irritation

Less common but important to monitor:

• Bleeding skin
• Chapped or swollen lips
• Numbness
• Red and itchy rashes
• Cold sores
• Rosacea

Eflornithine, used in both topical and oral forms, can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects. It's essential to inform your healthcare provider about all medications, including over-the-counter drugs and supplements, before starting eflornithine.

Topical Eflornithine Interactions:

When applied to the skin, eflornithine may interact with other topical treatments, leading to increased skin irritation. Notable interactions include:

• Fluorouracil (Efudex): Combining this chemotherapy agent with eflornithine can heighten skin sensitivity and irritation.

• Topical Retinoids (e.g., Tretinoin, Retin-A): Using these acne or anti-aging treatments alongside eflornithine may result in enhanced redness and irritation.

• Hydroquinone (Melquin): This skin-lightening agent, when used with eflornithine, can cause additional skin irritation.

Oral Eflornithine Interactions:

Oral eflornithine can interact with various medications, including:

• Live Vaccines: Eflornithine may reduce the effectiveness of live vaccines such as measles, mumps, rubella, and yellow fever. It's advisable to avoid these vaccines during eflornithine treatment.

• Immunosuppressants (e.g., Alefacept): Concurrent use can increase the risk of serious infections. Monitor for signs like fever, chills, or sore throat.

• Chemotherapy Agents (e.g., Cyclophosphamide, Docetaxel): Combining these with eflornithine may elevate the risk or severity of adverse effects.

General Recommendations:

• Inform Your Healthcare Provider: Always disclose all medications and supplements you're taking to assess potential interactions.

• Monitor for Side Effects: Be vigilant for unusual symptoms and report them promptly.

• Avoid Certain Vaccines: Discuss vaccination plans with your doctor to ensure safety during eflornithine therapy.

By staying informed and communicating openly with your healthcare provider, you can effectively manage potential drug interactions with eflornithine.