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It is essential to understand the safety information and warnings associated with using this medication. If you have any concerns, please discuss them with your healthcare provider. Below are key points to consider:

• Liver Damage: Fenofibrate may cause severe liver damage, potentially leading to liver failure and death. Regular blood tests are necessary before and during treatment to monitor liver health. If liver problems occur, discontinuing the medication may be required. Do not use fenofibrate if you have existing liver issues. Seek immediate medical attention if you experience symptoms such as abdominal swelling, pain, nausea, vomiting, jaundice, dark or bloody stools, or confusion. Higher doses increase the risk.

• Muscle Damage (Myopathy and Rhabdomyolysis): Fenofibrate can increase the risk of muscle damage, which may result in muscle breakdown affecting other organs. This risk is heightened if combined with other muscle-affecting drugs like statins, or in individuals with diabetes or low thyroid hormones. Consult your provider about any medications you are taking. Promptly seek medical help if you experience fever, sudden muscle pain, cramps, weakness, or dark urine. Older adults and those with kidney issues are at increased risk.

• Kidney Effects: Clinical studies have shown elevated creatinine levels in some fenofibrate users, indicating potential kidney issues. While it is uncertain if the medication directly harms kidneys, starting at a lower dose and performing regular kidney function tests is advised. Those over 65, or with diabetes or kidney problems, should be vigilant. Report changes in urination or dark urine to your provider.

• Allergic Reactions: Fenofibrate may cause severe allergic reactions, including life-threatening symptoms like facial swelling and anaphylaxis. Discontinue use immediately and seek emergency care if you notice hives, swelling, or breathing difficulties.

• Gallstones: The medication can increase the risk of gallstones and should not be used by individuals with gallbladder problems. Report any abdominal or back pain, nausea, or vomiting to check for gallstones.

• Pancreatitis: Rare cases of pancreas inflammation have been reported. This could be due to high triglyceride levels or other factors. Contact your provider if you experience sudden abdominal pain, nausea, vomiting, or stomach fluid buildup.

• Blood Clots: Fenofibrate may heighten the risk of blood clots in the lungs (PE) or legs (DVT). Seek immediate medical attention for chest pain, breathing difficulty, leg swelling, or tender, warm skin.

Contraindications

Avoid using this medication if you have:

• Severe kidney disease or are on dialysis
• Liver disease
• Gallbladder disease
• Are a nursing mother

Consult your healthcare provider if any of these conditions apply to you before starting fenofibrate.

When taking this medication, you may experience some common side effects such as liver damage, which occurs in about 8% of users, lung problems in 6%, and stomach pain in 5%. Less commonly, individuals may notice back pain, headaches, a stuffy nose, nausea, constipation, or a rash. These are usually mild but should be discussed with your healthcare provider if they persist or worsen.

There are rare but severe side effects that require immediate medical attention. These include gallstones, liver problems, and muscle issues that can lead to a condition called rhabdomyolysis. Symptoms to watch for are persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the skin or eyes, and dark urine. Additionally, severe muscle pain accompanied by fever, unusual tiredness, or changes in urine output should be promptly reported.

Although serious allergic reactions are uncommon, they can occur. Symptoms might include a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, and difficulty breathing. Other serious reactions include blood clots, indicated by chest pain, sudden leg pain or swelling, and signs of infection such as a persistent sore throat or fever.

Furthermore, a severe lowering of HDL cholesterol levels has been reported, so regular monitoring is advised. If you experience easy bleeding or bruising, or unusual tiredness, inform your healthcare provider. It is important to keep all lab appointments and stay vigilant for any other side effects. If you notice anything unusual, contact your healthcare provider for guidance.

When taking Fenofibric acid, it's essential to be aware of potential drug interactions. Avoid using fenofibrate-containing products simultaneously, as Fenofibric acid and fenofibrate are very similar and should not be used together.

Furthermore, Fenofibrate can interact with several other medications. It is crucial to inform your healthcare provider about all medicines and supplements you are taking, including prescriptions, over-the-counter drugs, and herbal supplements. Some medications, like Ciprofibrate, should not be used with Fenofibrate. Other drugs, such as Acenocoumarol, Anisindione, Atorvastatin, Colchicine, Dicumarol, Fluvastatin, Lovastatin, Phenprocoumon, Pitavastatin, Pravastatin, Rosuvastatin, Simvastatin, and Warfarin, are generally not recommended but may be necessary in some cases. Your doctor may adjust the dosage or frequency if used together. Additionally, using Fenofibrate with medications like Colestipol, Cyclosporine, Ezetimibe, and Rosiglitazone may increase the risk of side effects, but it might be the most effective treatment. Your doctor will guide you in such situations. Always consult with your healthcare provider for personalized advice.