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This safety and warning information outlines important considerations for the use of flurandrenolide (Cordran). Please review these points carefully and consult your healthcare provider if you have any questions or concerns.

• Hormonal Effects and Withdrawal: Overuse of flurandrenolide through skin absorption can disrupt your hormonal balance, particularly cortisol, leading to symptoms such as fatigue, nausea, and muscle pain. These usually resolve after discontinuation, but severe cases may require further treatment. Excessive use can also lead to increased blood sugar levels and, in children, possibly affect growth. To minimize these risks, use the medication strictly as prescribed, especially when applying it over large areas, for prolonged periods, or under occlusive dressings.

• Skin Irritation: Avoid using flurandrenolide on the face unless directed by a healthcare professional, as it can cause skin thinning and damage even with short-term application. Apply the smallest effective amount for the shortest duration to reduce these risks. Particular caution is advised when applying to skin folds or the face.

• Infection Risk: The use of flurandrenolide can suppress your immune response, making it harder to fight infections, including on the skin. If you develop a skin infection while using this medication, it should be treated with appropriate antifungal or antibacterial drugs. Be alert for signs of infection such as redness, swelling, pain, or pus at the application site and contact your healthcare provider immediately if these occur.

Contraindications:

• Do not use flurandrenolide on areas where skin folds or areas rub against each other, or on wounds or lesions that are leaking fluid, particularly when using Cordran Tape. If any of these conditions apply, consult your healthcare provider before use to avoid serious health risks.

Common side effects:

• burning
• itching
• irritation
• dryness
• redness of the skin

Less common but important to monitor:

• stretch marks
• skin thinning
• discoloration
• acne
• excessive hair growth
• folliculitis
• worsening skin infections

Serious side effects:

• extreme fatigue
• weight loss
• headaches
• swollen ankles or feet
• increased thirst or urination
• vision problems
• severe allergic reactions
• rash
• significant swelling
• severe dizziness
• trouble breathing