Diabetes type 2Tolbutamide coupons
Tolbutamide

Tolbutamide Coupons & Savings Card – Discount Prices from $11.60

Tolbutamide is an oral medication designed to help manage blood sugar levels in individuals with type 2 diabetes, particularly when dietary changes alone are insufficient. Although effective, this medication, in both brand and generic forms, has been discontinued and is no longer available in the United States.
Our coupons are free to use. Before paying, show the pharmacist your Tolbutamide savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Tolbutamide prices will update based on your prescription needs. Above our Tolbutamide coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Tolbutamide at the lowest price with our prescription discount card.

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500MG, Tolbutamide (30 Tablets)

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$47.00

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$11.60

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$22.59

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Tolbutamide savings card

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Tolbutamide dosage forms

Use our Tolbutamide 500MG coupon with prices from $11.60 for 30 Tablets. You can also use our Tolbutamide 500MG coupon with prices from $72.79 for 90 Tablets. We have a Tolbutamide 500MG coupon with prices from $42.19 for 60 Tablets.
DosageQuantityPrice fromPer unit
500MG30 Tablets$11.60$0.39
500MG90 Tablets$72.79$0.81
500MG60 Tablets$42.19$0.70
Show more dosage forms >

Tolbutamide Warnings

Tolbutamide is an oral medication used to manage type 2 diabetes by stimulating insulin release from the pancreas. While it can be effective in controlling blood sugar levels, there are important safety considerations to be aware of.

Increased Risk of Cardiovascular Mortality

A significant study known as the University Group Diabetes Program (UGDP) found that patients treated with tolbutamide had a cardiovascular mortality rate approximately 2.5 times higher than those managed with diet alone. This finding led to concerns about the cardiovascular safety of tolbutamide and similar medications.

Risk of Severe Hypoglycemia

Tolbutamide can cause severe low blood sugar (hypoglycemia), especially in certain situations. Factors that increase this risk include:

  • Renal or Hepatic Insufficiency: Impaired kidney or liver function can lead to higher levels of tolbutamide in the blood, increasing the likelihood of hypoglycemia.

  • Elderly or Malnourished Patients: These individuals may be more susceptible to the blood sugar-lowering effects of tolbutamide.

  • Adrenal or Pituitary Insufficiency: Conditions affecting these glands can heighten the risk of hypoglycemia.

  • Situations of Increased Stress: Events such as fever, trauma, infection, or surgery can disrupt blood sugar control, necessitating careful monitoring and possible adjustments in medication.

Hemolytic Anemia in G6PD Deficiency

Patients with a deficiency in glucose 6-phosphate dehydrogenase (G6PD) may experience hemolytic anemia—a condition where red blood cells are destroyed faster than they can be made—when treated with tolbutamide. It's advisable for individuals with G6PD deficiency to consider alternative treatments.

Use During Pregnancy and Breastfeeding

Tolbutamide is generally not recommended during pregnancy, particularly in the first trimester, due to potential risks to the developing fetus. Additionally, the medication can pass into breast milk, posing a risk of hypoglycemia in nursing infants. Therefore, breastfeeding while taking tolbutamide is not advised.

Alcohol Consumption

Consuming alcohol while on tolbutamide can lead to a disulfiram-like reaction, characterized by flushing, nausea, vomiting, and palpitations. It's recommended to avoid alcohol during treatment with this medication.

Monitoring and Precautions

Regular monitoring of blood and urine glucose levels is essential while taking tolbutamide. Patients should be educated on recognizing signs of hypoglycemia and understand the importance of adhering to dietary guidelines and exercise regimens. Any changes in health status, such as illness or stress, should be promptly discussed with a healthcare provider to adjust treatment as necessary.

Given these considerations, it's crucial to have an open dialogue with your healthcare provider to determine if tolbutamide is the appropriate medication for your diabetes management and to understand the necessary precautions to ensure its safe use.

Tolbutamide Side Effects

Tolbutamide is a medication used to manage type 2 diabetes by helping control blood sugar levels. While effective, it can cause various side effects, ranging from mild to severe. Common Side Effects:

  • Gastrointestinal Issues: Some individuals may experience nausea, heartburn, or a feeling of fullness in the upper abdomen. These symptoms are generally mild and often diminish as the body adjusts to the medication.
  • Skin Reactions: Mild skin reactions, such as itching or rash, may occur. These are typically transient and may resolve with continued use. Serious Side Effects:
  • Hypoglycemia (Low Blood Sugar): Tolbutamide can lower blood sugar levels too much, leading to symptoms like dizziness, sweating, shaking, rapid heartbeat, hunger, and confusion. In severe cases, it can cause loss of consciousness or seizures. It's important to recognize these signs and treat them promptly with a quick source of sugar.
  • Liver Issues: Signs of liver problems include yellowing of the skin or eyes (jaundice), dark urine, light-colored stools, persistent abdominal pain, or unusual fatigue. If you notice any of these symptoms, contact your healthcare provider immediately.
  • Blood Disorders: Although rare, tolbutamide may affect blood cell counts, leading to conditions like anemia or a decrease in white blood cells. Symptoms can include unusual bruising or bleeding, persistent sore throat, or frequent infections.
  • Allergic Reactions: Severe allergic reactions are uncommon but can occur. Symptoms may include swelling of the face, lips, tongue, or throat, difficulty breathing, or severe skin reactions. Seek immediate medical attention if these occur. Other Considerations:
  • Sun Sensitivity: Tolbutamide may increase sensitivity to sunlight, leading to sunburn-like reactions. It's advisable to use sun protection and limit sun exposure while taking this medication.
  • Weight Gain: Some individuals may experience weight gain while on tolbutamide. Maintaining a balanced diet and regular exercise can help manage this effect. It's crucial to monitor for these side effects and communicate any concerns with your healthcare provider. Regular check-ups and blood tests can help ensure the medication is working effectively and safely.

Tolbutamide Interactions

Tolbutamide, a medication used to manage type 2 diabetes, can interact with various substances, potentially affecting its effectiveness and safety. Understanding these interactions is crucial for maintaining optimal blood sugar control and avoiding adverse effects.

Medications That May Increase Tolbutamide's Effectiveness:

Certain drugs can enhance tolbutamide's blood sugar-lowering effects, increasing the risk of hypoglycemia (low blood sugar). These include:

  • Antifungal Agents: Medications like Ketoconazole and Fluconazole can slow the breakdown of tolbutamide in the body, leading to higher drug levels and a greater risk of hypoglycemia.

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Drugs such as Aspirin and Meloxicam may amplify tolbutamide's hypoglycemic effects.

  • Beta-Blockers: Medications like Atenolol and metoprolol can mask the symptoms of low blood sugar, making it harder to recognize and treat hypoglycemia promptly.

Medications That May Decrease Tolbutamide's Effectiveness:

Some substances can reduce tolbutamide's ability to lower blood sugar, potentially leading to hyperglycemia (high blood sugar). These include:

  • Corticosteroids: Drugs such as Prednisone can increase blood sugar levels, counteracting tolbutamide's effects.

  • Thiazide Diuretics: Medications like Hydrochlorothiazide may elevate blood sugar, diminishing tolbutamide's efficacy.

  • Phenobarbital: This drug can speed up the metabolism of tolbutamide, reducing its effectiveness.

Alcohol Interaction:

Consuming alcohol while taking tolbutamide can lead to a disulfiram-like reaction, characterized by flushing and nausea. Additionally, alcohol may increase the risk of hypoglycemia. It's advisable to avoid alcohol during tolbutamide therapy.

Managing Drug Interactions:

To minimize the risk of adverse interactions:

  • Inform Healthcare Providers: Always disclose all medications, including over-the-counter drugs and supplements, to your doctor or pharmacist.

  • Monitor Blood Sugar Levels: Regularly check your blood glucose to detect any changes that might indicate an interaction.

  • Adjust Dosages as Needed: Your healthcare provider may need to modify the doses of tolbutamide or other medications to maintain proper blood sugar control.

By being aware of these potential interactions and working closely with your healthcare team, you can effectively manage your diabetes while minimizing the risk of complications.

Tolbutamide FAQs
Why was tolbutamide discontinued?

Tolbutamide was discontinued in some markets primarily due to the availability of newer and more effective medications for managing type 2 diabetes. These newer drugs often have improved safety profiles and offer better glycemic control. Additionally, concerns about the risk of cardiovascular events associated with tolbutamide may have contributed to its discontinuation. However, it is important to note that tolbutamide may still be available in certain regions or under specific circumstances.

Yes, tolbutamide is a sulfonylurea. It is an oral medication used to help control blood sugar levels in individuals with type 2 diabetes.

Tolbutamide is a sulfonylurea class medication that works by stimulating the release of insulin from the beta cells of the pancreas. It achieves this by binding to and inhibiting the ATP-sensitive potassium channels on the beta cell membrane. This inhibition leads to cell depolarization, opening of voltage-gated calcium channels, and an influx of calcium ions, which ultimately triggers the exocytosis of insulin-containing granules.

Sulfonylureas, such as tolbutamide, are a class of oral medications used to manage type 2 diabetes. They work by stimulating the pancreas to release more insulin, which helps lower blood sugar levels. These medications are typically prescribed when diet and exercise alone are insufficient to control blood glucose levels.

Tolbutamide is not commonly used today primarily due to the availability of newer and more effective medications for managing type 2 diabetes. These newer drugs often have better safety profiles, fewer side effects, and improved efficacy in controlling blood glucose levels. Additionally, tolbutamide has been associated with a higher risk of cardiovascular events compared to some of the newer agents. As a result, healthcare providers tend to prefer prescribing these newer options.