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Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), carries certain risks that users should be aware of. It is important to understand these risks and precautions to ensure safe usage of the medication.

• Diclofenac may infrequently raise the risk of heart attack or stroke. This risk can occur at any time during the use of the drug but is heightened with prolonged use. The risk may be more pronounced in older adults or individuals with heart disease or increased risk factors for heart disease, such as smoking, family history, high blood pressure, or diabetes.
• Do not use diclofenac immediately before or after undergoing heart bypass surgery (CABG).
• There is a rare but serious risk of potentially fatal bleeding in the stomach or intestines, which can occur without prior symptoms. Older adults are at a higher risk for this side effect.
• Discontinue use of diclofenac and seek immediate medical attention if you experience severe stomach or abdominal pain, black or bloody stools, vomit resembling coffee grounds, chest pain, pain spreading to the jaw or left arm, shortness of breath, unusual sweating, confusion, weakness on one side of the body, sudden vision changes, or difficulty speaking.

It is crucial to discuss the potential benefits and risks of using diclofenac with your doctor or pharmacist to ensure that it is appropriate for your condition.

When using this medication, you might experience mild skin irritation or redness at the application site. These effects are common and generally not a cause for concern unless they persist or worsen. Additionally, this medication can cause an increase in blood pressure. It is advisable to monitor your blood pressure regularly and consult a healthcare professional if you notice elevated readings.

There are some serious side effects associated with this drug that require immediate medical attention. These include signs of kidney problems, such as changes in urination, and symptoms indicative of heart failure, like swelling of the ankles/feet, unusual tiredness, or sudden weight gain. Although rare, this medication can lead to severe liver disease, which can be potentially fatal. Watch for symptoms such as persistent nausea or vomiting, loss of appetite, abdominal pain, jaundice (yellowing of the skin or eyes), or dark urine, and seek medical help promptly if they occur.

A very serious allergic reaction to this medication is rare but warrants immediate medical attention. Symptoms might include fever, swollen lymph nodes, rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. If you experience any side effects not mentioned here, it's important to communicate with your healthcare provider for advice.

Certain medications can interact with this drug, potentially causing adverse effects. These include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Losartan and Valsartan, Cidofovir, corticosteroids like Dexamethasone and Prednisone, Lithium, Methotrexate, and diuretics such as Furosemide. Additionally, using this medication with other products applied to the treated skin can also lead to interactions.

This drug may increase bleeding risk if combined with other medications that have similar effects, such as antiplatelet drugs like Clopidogrel and anticoagulants like Dabigatran, Enoxaparin, and Warfarin, as well as Erlotinib.

Be cautious with over-the-counter medications, as many contain pain relievers or fever reducers like Aspirin and NSAIDs (Ibuprofen, Naproxen, or Ketorolac), which are similar to Diclofenac and could raise the likelihood of side effects when used together. However, if your doctor has prescribed low-dose aspirin (81-162 milligrams daily) for heart attack or stroke prevention, continue taking it unless advised otherwise by your healthcare provider. For more information, consult your doctor or pharmacist.