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This medication comes with important safety warnings and precautions that need to be carefully reviewed. Discuss any concerns with your healthcare provider to ensure safe use.

• Electrolyte and Fluid Imbalance: Use of indapamide may lead to dehydration and an imbalance of electrolytes such as sodium, potassium, magnesium, or chloride. These imbalances can exacerbate liver or kidney problems and, in severe liver conditions, may even lead to coma. Be vigilant for symptoms like dry mouth, thirst, weakness, fatigue, drowsiness, muscle pain, dizziness, increased heart rate, vomiting, or nausea, and report them to your provider. Populations at higher risk include those with kidney or liver conditions, women, older adults, individuals taking higher doses of indapamide or corticosteroids, and those with parathyroid issues.

• Gout: Indapamide can increase uric acid levels, potentially triggering or worsening gout. Those with a personal or family history of gout or kidney problems are at greater risk. Contact your healthcare provider immediately if you experience swollen, red, and painful joints.

• High Blood Sugar Levels: Indapamide can raise blood sugar levels, posing a risk particularly for individuals with diabetes. Regularly monitor your blood sugar and inform your provider if there are consistent changes, so medication adjustments can be made.

• Vision Problems: Individuals with sulfa or penicillin allergies may experience vision changes shortly after starting indapamide. Report any visual changes or eye pain to your doctor immediately and cease taking the medication. Surgical intervention may be necessary to prevent permanent vision loss.

• Allergic Reactions: Those with sulfa allergies may experience similar allergic reactions to indapamide. Ensure your healthcare provider and pharmacist are aware of any severe medication allergies. Discontinue use and seek medical attention if you notice a rash or other allergic symptoms.

Contraindications

Do not use this medication if you have the following conditions, as it can lead to serious health risks. Consult your healthcare provider before use if you:

• Have difficulty urinating.
• Have a history of allergies to sulfa medications.

Be sure to follow these guidelines closely to ensure safe use of indapamide.

Common side effects:

• Headaches
• Body or back pain
• Dizziness
• Nasal congestion
• Fatigue
• Muscle cramps
• Nervousness
• Anxiety
• Irritability

Less common but important to monitor:

• Drowsiness
• Difficulty sleeping
• Feelings of depression
• Blurred vision
• Constipation
• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Chest pain
• Indigestion
• Coughing
• Throat pain
• Conjunctivitis (pink eye)
• Weight loss
• Irregular heartbeat
• Increased frequency of urination
• Tingling sensations
• Dry mouth

Indapamide is a medication commonly prescribed to manage high blood pressure and fluid retention. While effective, it's important to be aware of potential interactions with other substances that could affect its efficacy or lead to adverse effects.

Interactions with Other Medications:

• Heart Medications: Combining indapamide with certain heart medications, such as Digoxin, can increase the risk of irregular heartbeats due to potential potassium depletion.

• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Medications like Ibuprofen or Naproxen may reduce indapamide's effectiveness in lowering blood pressure and could increase the risk of kidney issues.

• Other Blood Pressure Medications: Using indapamide alongside other antihypertensive drugs, including ACE inhibitors (e.g., Ramipril) or angiotensin receptor blockers (e.g., Candesartan), may lead to excessively low blood pressure or kidney complications.

• Diuretics: Taking indapamide with other diuretics can result in significant fluid and electrolyte loss, raising the risk of dehydration and imbalances.

• Lithium: Indapamide can elevate lithium levels in the blood, potentially leading to toxicity, which may cause tremors, confusion, and kidney damage.

Interactions with Food and Alcohol:

• Alcohol: Consuming alcohol while on indapamide can enhance the medication's blood pressure-lowering effects, possibly causing dizziness or fainting.

• Potassium-Rich Foods: Indapamide may lower potassium levels, so it's advisable to include potassium-rich foods in your diet to help maintain balance.

Herbal Supplements:

• Potassium Supplements: These can alter blood potassium levels and affect how indapamide works.

• Heartburn and Indigestion Remedies: Some contain high sodium levels, which can counteract indapamide's effectiveness.

It's essential to inform your healthcare provider about all medications, supplements, and herbal remedies you're taking to avoid potential interactions. Regular monitoring of blood pressure, kidney function, and electrolyte levels is recommended to ensure safe and effective use of indapamide.