Metolazone

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Metolazone is a thiazide-like diuretic, commonly known as a "water pill," designed to help your body eliminate excess fluids by increasing urine output. It is primarily used to manage high blood pressure, which can aid in preventing strokes, heart attacks, and kidney issues. Additionally, Metolazone effectively reduces swelling (edema) associated with conditions like heart failure and kidney problems, thereby alleviating symptoms such as difficulty breathing. This medication is taken orally, usually once a day. While it is generally safe, some individuals may experience side effects like dizziness or an imbalance in electrolytes. Always consult with your healthcare provider before starting any new medication to ensure it is safe and appropriate for your condition.
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10MG, Metolazone (30 Tablets)

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CVS

$23.19

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$14.22

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$18.79

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$25.36

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$31.30

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Metolazone savings card

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CVS

$23.19

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Metolazone dosage forms

The average cost for 30 Tablets of Metolazone at 10MG is $14.22 with a free coupon. This is 16.93% off the average retail price of $84
DosageQuantityPrice fromPer unit
10MG30 Tablets$14.22$0.47
2.5MG30 Tablets$9.57$0.32
5MG30 Tablets$11.71$0.39

Metolazone Warnings

This medication comes with important safety information that you should be aware of before use. Please read the warnings carefully, and consult your healthcare provider if you have any questions or concerns.

  • Electrolyte Imbalance and Dehydration: Metolazone may alter the levels of electrolytes such as sodium, potassium, magnesium, and calcium in your body. This risk is heightened if you take high doses or do not consume adequate fluids. Regular blood tests may be necessary to monitor these levels and your kidney health. Be vigilant for symptoms like dry mouth, weakness, fatigue, dizziness, muscle pain or cramps, rapid heartbeat, vomiting, or nausea. Factors that increase risk include kidney issues, dehydration, diarrhea or vomiting, concurrent use of other electrolyte-affecting medications, high doses of metolazone, and exposure to hot weather.

  • Low Blood Pressure: Metolazone can lead to decreased blood pressure, causing lightheadedness or dizziness. These symptoms often resolve within a few days, but if they persist, contact your healthcare provider who may adjust your dosage or prescribe a different medication. The risk is higher if you consume alcohol or take other blood pressure-lowering medications.

  • Life-Threatening Skin Reactions: Although rare, metolazone is associated with severe skin reactions like Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. These conditions can be fatal. Seek emergency medical attention if you experience a painful, blistering rash, peeling skin, or flu-like symptoms such as fever, chills, body aches, nausea, or vomiting.

  • Severe Allergic Reactions: Individuals allergic to sulfa-containing medications may also react to metolazone. If you have a history of such allergies, inform your healthcare provider before starting treatment. Depending on the severity of past reactions, a lower dose may be recommended with close monitoring for signs of reaction. Seek immediate medical help if you notice a rash, hives, trouble breathing, or swelling of the face or neck.

  • Gout: Metolazone can increase the risk of gout attacks. Inform your healthcare provider if you have a history of gout so they can monitor you more closely.

  • Worsening Kidney Problems: In rare instances, metolazone may exacerbate kidney issues. Blood tests to assess kidney function are necessary before and during treatment. Report any decrease in urination or dark urine despite adequate fluid intake to your healthcare provider.

  • High Blood Sugar: Metolazone might raise blood sugar levels in some cases. If you have diabetes, monitor your blood sugar levels more frequently as instructed by your healthcare provider.

Contraindications: Do not use metolazone if you are not urinating at all or if you are in a coma resulting from severe liver disease. Always consult your healthcare provider if you have these conditions before starting metolazone.

Metolazone Side Effects

Common side effects:

  • Dizziness
  • Lightheadedness
  • Headache
  • Blurred vision
  • Loss of appetite
  • Stomach upset
  • Diarrhea
  • Constipation

Less common but important to monitor:

  • Unusual dry mouth or thirst
  • Muscle cramps or weakness
  • Irregular heartbeat
  • Fatigue
  • Elevated uric acid levels

Serious side effects:

  • Severe allergic reactions
  • Trouble breathing
  • Rash
  • Swelling of the face, lips, tongue, or throat
  • Signs of infection
  • Persistent sore throat
  • Fever
  • Numbness or tingling of the limbs
  • Decreased sexual ability
  • Signs of liver or kidney problems
  • Persistent nausea
  • Yellowing eyes or skin
  • Changes in urination

Metolazone Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

  • Aminolevulinic Acid
  • Gossypol
  • Licorice
Metolazone FAQs
What type of diuretic is metolazone?

Metolazone is classified as a thiazide-like diuretic.

Metolazone and Lasix (furosemide) are not the same. Both are diuretics, but they belong to different classes. Metolazone is a thiazide-like diuretic, while Lasix is a loop diuretic. They work in different parts of the kidney and may be used together in certain situations to enhance diuretic effect. However, they are distinct medications with different mechanisms of action.

The choice between furosemide and metolazone depends on the specific medical condition being treated and the patient's individual needs. Furosemide is a loop diuretic often used for conditions like heart failure, edema, and hypertension. Metolazone is a thiazide-like diuretic that can be used in similar conditions but is often used in combination with loop diuretics for enhanced diuretic effect. A healthcare provider would consider factors such as the patient's kidney function, electrolyte balance, and overall health status when determining which medication is more appropriate.

Metolazone should not be taken by individuals who have a known allergy to metolazone or any of its components. It is also contraindicated in patients with anuria (inability to urinate) and those with severe liver disease, as it may exacerbate these conditions. Additionally, caution is advised for individuals with severe kidney disease, electrolyte imbalances, or those who are pregnant or breastfeeding. It is important for patients to consult with their healthcare provider to determine if metolazone is appropriate for their specific health condition.

Metolazone belongs to the class of drugs known as thiazide-like diuretics.