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When considering the use of Seysara (sarecycline), it is crucial to be aware of the following safety warnings and contraindications. These details highlight potential risks and provide guidance on precautions necessary for safe use. It is recommended that you discuss any concerns with your healthcare provider.

• Pregnancy and Nursing: Seysara (sarecycline) should not be used during pregnancy or while breastfeeding, as it may lead to poor bone development and teeth discoloration in the child. The medication can be transferred through breast milk, potentially causing harm to a breastfed baby. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for safer alternatives. The highest risk occurs during the second and third trimesters of pregnancy and while currently breastfeeding.

• Infectious Diarrhea: There is an increased risk of developing an infection with Clostridioides difficile (C. diff), which can cause severe diarrhea. This risk is heightened if you are over 65 or have a weakened immune system. Inform your dermatologist if you have recently used other antibiotics. Discontinue Seysara and seek immediate medical attention if you experience fever, tiredness, or bloody or watery stools, as these may indicate C. diff-associated diarrhea (CDAD).

• Dizziness and Light-headedness: Seysara may cause dizziness or a sensation of the room spinning. Avoid activities that require full attention, such as driving, until you understand how the medication affects you. These symptoms may subside with continued use or upon discontinuation. Inform your healthcare provider if these symptoms persist.

• Intracranial Hypertension: Though rare, Seysara can increase brain pressure, leading to potential permanent vision changes. The risk is higher if used alongside other medications like isotretinoin. It's advisable to have a vision check before starting Seysara. Report any unusual headaches or blurred vision to your healthcare provider.

• Sun and Light Sensitivity: This medication increases skin sensitivity to sunlight or UV light, raising the risk of sunburn. Protect your skin by using sunscreen and wearing long sleeves, even on overcast days, and limit sun exposure.

• Drug-resistant Infections: Seysara may lead to infections from drug-resistant bacteria, fungi, or yeast, which are more challenging to treat. Contact your healthcare provider if you develop symptoms of infection, such as fever or chills.

Contraindications:

• Do not use Seysara if you have an allergy to any tetracycline antibiotics. Always consult your healthcare provider to ensure this medication is safe for you.

When taking this medication, you might experience some common side effects such as nausea, lightheadedness, dizziness, or a sensation of spinning. These are generally mild, but if they persist or worsen, it's important to consult your healthcare provider. Additionally, some users report vaginal yeast infections.

Rarely, this medication can lead to more serious side effects that require immediate medical attention. These include an increase in brain pressure, known as intracranial hypertension, which can result in severe headaches, vision changes like blurred or double vision, and persistent nausea or vomiting. This side effect is more common in women of childbearing age who are overweight or have previously experienced intracranial hypertension. Another serious condition, infectious diarrhea caused by C. difficile, may manifest as persistent or foul-smelling diarrhea, abdominal pain, cramping, or the presence of blood or mucus in the stool. If you observe such symptoms, avoid using anti-diarrhea or opioid products, as these can exacerbate the symptoms.

In rare instances, prolonged or repeated use of the medication could lead to oral thrush or a new vaginal yeast infection. Look out for symptoms such as white patches in your mouth or changes in vaginal discharge. Furthermore, although extremely uncommon, severe allergic reactions can occur, marked by symptoms such as fever, rash, persistent swelling of lymph nodes, itching or swelling particularly around the face, tongue, or throat, severe dizziness, and breathing difficulties. Should you experience any of these severe side effects, seek urgent medical assistance. Always reach out to your healthcare provider if you notice any unusual symptoms or side effects not mentioned here.