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When considering the use of Isradipine, it is crucial to be aware of potential risks and necessary precautions. Below are important safety considerations:

• Low Blood Pressure: Isradipine may lead to a significant drop in blood pressure, resulting in dizziness, fatigue, or lightheadedness, particularly when starting the medication or increasing the dose. Severe dizziness is uncommon but should be taken seriously. If you feel excessively dizzy, sit down slowly with support and inform your healthcare provider, as your dosage might need adjustment. Seek immediate medical attention if you fall and sustain a head injury.

• Heart Failure Concerns: For individuals with heart failure, regular monitoring by a healthcare provider is essential. Isradipine can decrease heart rate and complicate the heart's ability to pump blood efficiently, potentially exacerbating heart failure. The risk is elevated if you are concurrently taking beta blockers (medications ending in -olol). Watch for symptoms such as difficulty breathing, fatigue, or swelling in the hands or feet, and report these to your healthcare provider promptly.

There are no known contraindications for Isradipine. Always consult with your healthcare provider to discuss any concerns and ensure safe use of this medication.

Common side effects:

• Dizziness
• Nausea
• Headaches
• Tiredness
• Flushing
• Swelling of the ankles, feet, or hands

Serious side effects:

• Fainting
• Fast, irregular, or pounding heartbeat
• Changes in vision
• Worsening chest pain
• Heart attack
• Rash
• Itching
• Swelling of the face, tongue, or throat
• Severe dizziness
• Trouble breathing

Isradipine can interact with several other medications and supplements, potentially affecting its effectiveness. It's important to inform your doctor and pharmacist about all the medications and supplements you are taking, whether prescribed, over-the-counter, or herbal.

Certain drugs can impact how isradipine is removed from your body, which may alter its action. These include Cimetidine, azole antifungals like Itraconazole, macrolide antibiotics such as Erythromycin, rifamycins including Rifabutin, St. John's wort, and seizure medications like Phenytoin. Additionally, some products, especially those for colds, diet aids, or NSAIDs like Ibuprofen and Naproxen, might increase your blood pressure. Discuss with your pharmacist how to use these safely.

There are specific medications that should generally not be used with isradipine unless deemed necessary by your doctor. These include drugs like Mefloquine, acecainide, and several others listed, which may require dose adjustments if used together. Furthermore, some interactions can increase side effects, as seen with drugs such as amprenavir, Ketoconazole, and Rifampin. Your doctor will manage these interactions by adjusting dosages or the frequency of administration to ensure safe and effective treatment.