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This medication comes with important safety and warning information that outlines the potential risks and necessary precautions for its use. Please ensure you read these carefully and consult your healthcare provider if you have any questions or concerns.

• Heart Rhythm Concerns: On rare occasions, using diltiazem (Cardizem) may lead to heart rhythm issues, including a slow heart rate. The likelihood of experiencing this side effect increases if you are concurrently taking medications such as digoxin or beta-blockers. If you experience symptoms such as weakness or lightheadedness, these could indicate heart-related problems, and you should contact your healthcare provider.

• Low Blood Pressure: Diltiazem (Cardizem) might cause a drop in blood pressure, particularly if you are already on blood pressure medications. Inform your healthcare provider immediately if you notice any signs of low blood pressure, like dizziness, weakness, confusion, or blurred vision.

• Liver Health: Although very rare, there have been instances of liver damage occurring within the first couple of weeks of starting diltiazem (Cardizem). Typically, this liver damage is mild and resolves on its own within 1 to 2 months after discontinuation of the medication. If liver issues arise, your healthcare provider will likely conduct blood tests to monitor liver function. Those with a history of liver disease should be particularly cautious.

Contraindications: There are certain conditions where this medication should not be used due to the potential for serious health risks. If any of the following apply to you, it is crucial to consult your healthcare provider before starting this medication:

• Sick sinus syndrome, unless you have a ventricular pacemaker.
• Second- or third-degree atrioventricular (AV) block, unless you have a ventricular pacemaker.
• Uncontrolled low blood pressure (systolic less than 90 mm Hg).
• Active myocardial infarction accompanied by lung congestion.

Always prioritize consultation with your healthcare provider to ensure safe and effective use of diltiazem (Cardizem).

When taking this medication, some individuals may experience common side effects such as dizziness, lightheadedness, weakness, nausea, flushing, constipation, and headache. These effects are usually mild, but if they persist or worsen, it's advisable to consult your healthcare provider. To help manage dizziness and lightheadedness, try rising slowly from sitting or lying positions.

In some cases, users may report additional side effects like swelling in the legs and feet, rash, stomach upset, dry mouth, nervousness, and diarrhea. While these are generally not severe, reaching out to a healthcare professional for guidance is recommended if they become bothersome.

More serious side effects require immediate medical attention. These include persistent nausea or vomiting, fainting, new or worsening symptoms of heart failure (like shortness of breath, unusual tiredness, or sudden weight gain), irregular or fast heartbeat, mental or mood changes, severe stomach pain, dark urine, or yellowing of the eyes or skin. Rare but severe allergic reactions, such as rash, itching or swelling, severe dizziness, or breathing difficulties, also necessitate urgent care.

While a very serious allergic reaction is rare, it's important to be vigilant and seek medical help if you notice any symptoms. Remember, this list is not exhaustive, and if you experience any other concerning effects, contacting your healthcare provider is a prudent course of action.

Diltiazem (Cardizem) can interact with various medications and supplements. It is crucial to inform your doctor and pharmacist about any other drugs or supplements you are taking, including prescription, over-the-counter, vitamins, or herbal products. Some interactions may lead to significant side effects or alter the effectiveness of the medications.

Certain medications should not be used concurrently with diltiazem. These include cisapride, Colchicine, eliglustat, Flibanserin, and lomitapide, as they can cause serious interactions.

Other drugs may require adjustments in dosage if used with diltiazem. These include abametapir, acalabrutinib, Acebutolol, and many others, as listed in the sources. In such cases, your healthcare provider may need to modify your treatment plan.

Additionally, some drugs may increase the risk of side effects when taken with diltiazem, yet the combination might be necessary for your treatment. These include alfuzosin, apixaban, Buspirone, and others. Your doctor might adjust the dosage or frequency of these medications.

Furthermore, some substances can affect the removal of diltiazem from the body, altering its effectiveness. For example, azole antifungals like Ketoconazole, Cimetidine, macrolide antibiotics like Erythromycin, rifamycins such as Rifabutin and Rifampin, and St. John's wort can all interfere with how diltiazem works.

Conversely, diltiazem can slow the elimination of other medications, which may affect their activity. This includes drugs like Aprepitant, buspirone, colchicine, and certain benzodiazepines like Triazolam and Midazolam.

Lastly, inform your pharmacist about any products you use that could increase heart rate or worsen chest pain, including cough-and-cold products, diet aids, or NSAIDs such as Ibuprofen and Naproxen, to ensure safe use.