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The following safety and warning information outlines potential risks and precautions associated with the use of Kelnor, a combination oral contraceptive. It is crucial to review this information carefully and discuss any concerns with your healthcare provider.

• Smoking and Blood Clots: Smoking while using Kelnor can greatly increase the risk of blood clots, which may lead to severe complications like heart attack or stroke. This risk is particularly higher for individuals over 35 who smoke 15 or more cigarettes daily. Consult your healthcare provider for safer contraceptive options if you smoke.

• Risk of Blood Clots: Kelnor contains ethinyl estradiol, an estrogen that can increase clot formation risk. Elevated risk factors include being over 35 and smoking, being over 40 even if you don’t smoke, recent surgery with extended bed rest, high blood pressure, high cholesterol, diabetes, obesity, taking Kelnor less than a month postpartum, and high estrogen doses.

• Cancer Risks: Long-term use of Kelnor may potentially elevate the risk of breast and cervical cancer, especially for those with a personal or family history of breast cancer. The risk of cervical cancer increases after five years of COC use.

• Liver Issues: Avoid Kelnor if you have liver problems, including viral infections or tumors, as it might increase the risk of benign liver tumors. Discontinue use and consult your doctor if you notice jaundice, fever, fatigue, loss of appetite, or dark urine.

• Gallbladder Problems: Kelnor may slightly raise the risk of gallbladder disease and gallstones. Discuss with your healthcare provider if you have a gallbladder disease history before starting Kelnor.

• Blood Sugar and Cholesterol Levels: Kelnor can increase blood sugar levels, particularly in those with prediabetes or diabetes. Discuss alternative contraceptives or monitoring strategies with your healthcare provider if you have a history of high blood sugar or triglycerides.

• High Blood Pressure: Kelnor may cause elevated blood pressure, especially in older individuals or long-term users. Discuss the risks and benefits with your healthcare provider if you have a history of uncontrolled high blood pressure or kidney issues.

• Headaches: Inform your healthcare provider if you develop new or worsening migraines while taking Kelnor. Persistent or severe headaches may require discontinuation of the medication for further evaluation.

• Irregular Vaginal Bleeding: Irregular bleeding or spotting may occur, particularly in the first three months of Kelnor use. Continue the medication as directed, but inform your healthcare provider if bleeding persists, becomes heavier, or if you miss a period.

• Drug Interactions: Certain medications may affect Kelnor’s efficacy and side effect profile. Share all current and planned medications with your healthcare provider and pharmacist to ensure safe usage.

Contraindications: Do not use Kelnor if you have or have had:

• Blood clots (e.g., DVT, PE) or clotting disorders.
• Heart attack or cerebrovascular disease, such as stroke.
• Coronary artery disease.
• Breast cancer or reproductive system cancers.
• Unexplained abnormal vaginal bleeding.
• Jaundice during pregnancy or while on birth control.
• Liver tumors or liver problems.
• Are currently pregnant or taking specific hepatitis C medications containing ombitasvir/paritaprevir/ritonavir.

Make sure to consult your healthcare provider before starting Kelnor if any of these conditions apply to you.

Common side effects:

• Nausea
• Vomiting
• Abdominal cramps
• Bloating
• Irregularities in menstrual cycles
• Swelling
• Melasma
• Breast tenderness or swelling
• Changes in weight

Less common but important to monitor:

• Vaginal yeast infections
• Mood changes
• Skin rashes
• Discomfort while wearing contact lenses

Serious side effects:

• Heart attack symptoms (chest pain and dizziness)
• Stroke symptoms (sudden numbness or confusion)
• Deep vein thrombosis (leg cramps and swelling)
• Pulmonary embolism (chest pain and difficulty breathing)
• Blood clot in the eye (vision problems)
• Liver issues (yellowing skin or eyes)

When taking Kelnor 1/35, it's important to be aware of potential interactions with other medications, supplements, and lifestyle factors that could affect its effectiveness or increase the risk of side effects.

Medications That May Reduce Kelnor 1/35's Effectiveness:

• Antibiotics: Certain antibiotics, such as Rifampin, may decrease the effectiveness of Kelnor 1/35, potentially leading to breakthrough bleeding or unintended pregnancy.

• Anticonvulsants: Medications like Phenytoin, Carbamazepine, and barbiturates can lower the levels of contraceptive hormones in your body, reducing the pill's effectiveness.

• HIV and Hepatitis C Treatments: Some treatments for HIV and hepatitis C can either increase or decrease the levels of contraceptive hormones, affecting both efficacy and side effects.

Medications That May Increase Side Effects:

• Corticosteroids: Drugs like Cortisone may have increased blood levels when taken with Kelnor 1/35, leading to a higher risk of side effects such as swelling, weight gain, and elevated blood pressure.

• Melatonin: Taking melatonin supplements alongside Kelnor 1/35 can increase melatonin levels in the blood, potentially causing excessive drowsiness, dizziness, and irritability.

Lifestyle Factors:

• Smoking: Smoking while using Kelnor 1/35 significantly increases the risk of serious cardiovascular events, especially in women over 35. It's strongly advised to avoid smoking during contraceptive use.

• Grapefruit Juice: Consuming grapefruit juice may increase the side effects of estrogen in some women, such as nausea and breast tenderness. It's advisable to maintain a consistent intake of grapefruit products and report any unusual side effects to your healthcare provider.

Other Considerations:

• Vitamin C (Ascorbic Acid): High doses of vitamin C may increase estrogen levels, potentially leading to side effects.

• Caffeine: Kelnor 1/35 can slow the breakdown of caffeine in the body, possibly intensifying caffeine-related side effects like jitteriness or insomnia.

Always inform your healthcare provider about all medications, supplements, and lifestyle habits to ensure Kelnor 1/35 is safe and effective for you.