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The following information outlines crucial safety warnings and precautions for using mesalamine DR (Lialda). It is important to understand these risks and consult your healthcare provider if you have any questions or concerns.

• Kidney Damage and Stones: Mesalamine DR (Lialda) may cause kidney damage, especially if you have pre-existing kidney conditions or are using medications that affect the kidneys, such as NSAIDs and diuretics. Regular blood or urine tests may be needed to monitor your kidney function. Be alert for symptoms like changes in urination, fatigue, decreased appetite, and muscle cramps, and inform your healthcare team if they occur.

• Acute Intolerance Syndrome: Although rare, some individuals may experience acute intolerance syndrome within 1 to 3 weeks of starting mesalamine DR (Lialda). Symptoms usually resolve after discontinuation or corticosteroid treatment.

• Severe Allergic Reactions: Mesalamine DR (Lialda) can cause severe allergic reactions, including life-threatening ones like anaphylaxis. Seek emergency medical care immediately if you experience hives, rash, swelling of lips or tongue, or difficulty breathing.

• Severe Skin Reactions: Rare but serious skin conditions, such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and DRESS syndrome, can occur. Discontinue use and seek medical attention if you notice skin changes like rash, blisters, peeling, or redness, especially if accompanied by fever, sore throat, fatigue, or swollen lymph nodes.

• Liver Problems: Rare cases of liver failure have been reported in individuals with existing liver problems taking mesalamine DR (Lialda). Inform your doctor of any liver history prior to use. Seek immediate medical help for symptoms like severe nausea, vomiting, right-sided abdominal pain, fatigue, appetite changes, or yellowing of the skin or eyes.

• Caution with Bowel Obstruction: Avoid mesalamine DR (Lialda) if you have or are at risk for bowel obstruction, as it may prevent the medication from reaching the colon. Report symptoms such as severe stomach cramps, nausea, vomiting, constipation, or a swollen abdomen to your doctor.

• Photosensitivity: Those with skin conditions like eczema may experience increased sensitivity to sunlight or UV light while on mesalamine DR (Lialda), leading to easier sunburns. Take protective measures against sun exposure, even in winter or cloudy weather.

Contraindications:

• Avoid using mesalamine DR (Lialda) if you are allergic to aspirin or other salicylates, such as sulfasalazine, as it may pose serious health risks. Always consult with your healthcare provider for guidance.

When taking this medication, some common side effects may include headaches, abdominal pain, diarrhea, and changes in liver enzyme levels. These are generally mild, but if they persist or worsen, it's advisable to consult a healthcare provider. Other side effects that could occur include stomach bloating, indigestion, back pain, joint pain, fatigue, high blood pressure, rash, itching, and hair loss. While these are less common, any persistent or bothersome symptoms should be discussed with a healthcare professional.

In rare cases, more serious side effects can manifest, necessitating immediate medical attention. These include signs of kidney damage, such as reduced urination, dry and itchy skin, muscle cramps, and swelling in extremities. Kidney stones can also develop, indicated by difficulty urinating, bloody urine, fever, chills, and back or side pain. Liver-related issues might arise, presenting as stomach bloating, pain on the right side of the stomach, yellowing of the skin or eyes, and dark urine. Additionally, serious allergic reactions are a possibility, with symptoms like hives, swelling of the lips or tongue, and breathing difficulties, while severe skin reactions might include hives, blisters, peeling skin, redness, fever, sore throat, and swollen lymph nodes.

If any of these serious symptoms occur, seek urgent medical care. Always be vigilant about any unusual changes in your health while on this medication, and communicate with your healthcare provider about any concerns.

When taking mesalamine, it's important to avoid using similar medications like Balsalazide, olsalazine, or Sulfasalazine, as they can lead to adverse interactions. This drug might also affect the results of certain lab tests, such as those measuring urine normetanephrine levels, potentially causing false readings. Ensure that your healthcare providers and lab personnel are informed about your use of mesalamine.

Additionally, mesalamine (Lialda) may interact with a wide range of medications and supplements. It's crucial to inform your doctor and pharmacist about all the medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements. Some medications, such as various anti-inflammatory drugs and salicylates, are generally not recommended to be used with mesalamine unless necessary. In such cases, your doctor might adjust the dosage or frequency of either medication.

Furthermore, taking mesalamine with certain drugs like tamarind or Warfarin can increase the risk of side effects, although sometimes this combination might be essential for your treatment. Your doctor will carefully manage these combinations to ensure your safety.